Baculoviral IAP Repeat-Containing Protein 6

Preferred Label : Baculoviral IAP Repeat-Containing Protein 6;

NCIt synonyms : KIAA1289; Ubiquitin-Conjugating BIR Domain Enzyme Apollon; Apollon; BIRC6; Baculoviral IAP Repeat-Containing Protein-6;

NCIt definition : Baculoviral IAP repeat-containing protein 6 (4829 aa, 528 kDa) is encoded by the human BIRC6 gene. This protein is involved in both the inhibition of apoptosis and protein ubiquitination.;

NCIt note : Baculoviral IAP Repeat-Containing Protein 6, encoded by the BIRC6 gene, is a member of the IAP (inhibitors of apoptosis proteins) family and the ubiquitin-conjugating enzyme family. This protein is expressed as a 530-kD protein in gliomas and ovarian cancers. BIRC6 may protect cancer cells from undergoing apoptosis and resist to apoptosis in the presence of anticancer drugs. BIRC6 contains a 70-amino acid cysteine- and histidine-rich baculovirus IAP repeat (BIR) and a zinc-binding RING finger.;

Details

Origin ID

C28697;

UMLS CUI

C0910612;

OMIM relation
- Baculoviral iap repeat-containing protein 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BIRC6 protein, human [MeSH concept]
- BIRC6 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- BIRC6 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Inhibitor [NCIt concept]
- Regulatory Protein [NCIt concept]
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_chemical_classification
- IAP Family Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- BIR Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- UBC Domain [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_malfunction_associated_with_disease
- Glioma [NCIt concept]
- Malignant Ovarian Neoplasm [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Drug Resistance Process [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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