Preferred Label : UBC Domain;
NCIt synonyms : Ubiquitin-Conjugating Domain;
NCIt definition : The 16-kD UBC domain contains a conserved UBC motif and a conserved cysteine that
accepts activated ubiquitin from E1 enzyme to form a thiol ester. Basic residues at
the UBC domain N-terminus may be involved in E1 binding. UBC/E2 enzymes catalyze ubiquitination
of target proteins with or without E3 'N-end' recognizing proteins. E2s can be classified
on the basis of UBC structure. Poor at transferring ubiquitin to proteins on their
own, Class I proteins comprise simply the UBC domain and probably require an E3 to
ubiquitinate short-lived abnormal proteins prior to degradation. Class II enzymes
contain different acidic C-terminal extensions of the UBC domain that appear to involve
cellular localization or to mediate interaction with protein substrates for ubiquitination
that results in protein modification but not degradation. Class III E2s have N-terminal
extensions, but their function is unknown. (NCI);
Origin ID : C13907;
UMLS CUI : C1519739;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
