E3 Ubiquitin-Protein Ligase XIAP

Preferred Label : E3 Ubiquitin-Protein Ligase XIAP;

NCIt synonyms : X-linked Inhibitor of Apoptosis; X-Linked IAP; Apoptosis Inhibitor 3; X-Linked Inhibitor of Apoptosis Protein; IAP-Like Protein; Inhibitor of Apoptosis Protein 3; BIRC4; HILP; Baculoviral IAP Repeat-Containing Protein-4; ILP; EC 2.3.2.27; hIAP3; Baculoviral IAP Repeat-Containing Protein 4; EC 6.3.2.-, Formerly; hIAP-3; RING-Type E3 Ubiquitin Transferase XIAP; IAP-3;

NCIt definition : Baculoviral IAP repeat-containing protein 4 (497 aa, 57 kDa) is encoded by the human XIAP gene. This protein plays a role in both protein ubiquitination and the inhibition of apoptosis.;

NCIt note : Encoded BIRC4 Gene (IAP Family), Baculoviral IAP Repeat-Containing Protein 4 inhibits apoptosis through binding to TNF Receptor-associated factors TRAF1 and TRAF2. Similar to BIRC2, BIRC4 inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. BIRC4 also specifically inhibits cell-death proteases, caspase-3 and caspase-7. A novel transcript homologous to BIRC4 is expressed solely in the testis.;

Details

Origin ID

C20947;

UMLS CUI

C1173600;

Currated CISMeF NLP mapping
- X-Linked inhibitor of apoptosis protein [MeSH Descriptor]
- X-Linked inhibitor of apoptosis protein [MeSH concept]
False automatic mappings
- Inductive Machine Learning [EFMI term]
OMIM relation
- Inhibitor of apoptosis, X-linked [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- XIAP protein, human [MeSH Supplementary Concept]
- XIAP protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
- XIAP Gene [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Inhibitor [NCIt concept]
- Regulatory Protein [NCIt concept]
- Signaling Protein [NCIt concept]
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_chemical_classification
- IAP Family Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- BIR Domain [NCIt concept]
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- B-Cell Survival Pathway [NCIt concept]
- Caspase Cascade Pathway [NCIt concept]
- Mitochondria in Apoptotic Signaling Pathway [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]
is_target
- Dasminapant [NCIt concept]
- IAP Antagonist TQB3728 [NCIt concept]
- Idronoxil [NCIt concept]
- SMAC Mimetic BI 891065 [NCIt concept]
- Smac Mimetic BGB-24714 [NCIt concept]
- Smac Mimetic GDC-0152 [NCIt concept]
- Smac Mimetic LCL161 [NCIt concept]
- Tolinapant [NCIt concept]
- XIAP Antisense Oligonucleotide AEG35156 [NCIt concept]
- Xevinapant [NCIt concept]

Keyword's position in hierarchy(ies) :

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