Preferred Label : IAP Antagonist TQB3728;
NCIt synonyms : Smac Mimetic Compound TQB3728;
NCIt definition : An orally bioavailable, second mitochondria-derived activator of caspases (SMAC)-mimetic
and an antagonist of inhibitor of apoptosis proteins (IAPs), with potential apoptosis-inducing
and antineoplastic activities. Upon oral administration, IAP antagonist TQB3728 selectively
targets, binds to and inhibits the activity of IAPs including X chromosome-linked
IAP (XIAP) and cellular IAPs 1 (c-IAP1) and 2 (c-IAP2). This may restore and promote
the induction of apoptosis through apoptotic signaling pathways and enhance proteasomal
degradation of IAPs. Additionally, TQB3728 may work synergistically with cytotoxic
drugs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many
cancer cell types, suppressing apoptosis by binding and inhibiting active caspases-3,
-7 and -9 via their BIR (baculoviral lAP repeat) domains.;
Molecule name : TQB-3728; TQB 3728;
NCI Metathesaurus CUI : CL1647868;
Origin ID : C178400;
UMLS CUI : C5555008;
Semantic type(s)
- concept_is_in_subset
- has_target
