Preferred Label : SMAC Mimetic BI 891065;
NCIt related terms : PROPANAMIDE, N-(5-(2-(2-METHOXY-3-PYRIDINYL)-7-METHYLIMIDAZO(1,2-A)PYRIDIN-3-YL)-6-(2-(1-METHYL-6-ISOQUINOLINYL)ETHYNYL)-2-PYRIDINYL)-2-(METHYLAMINO)-,
(2S)-;
NCIt definition : A mimetic of second mitochondrial-derived activator of caspases (Smac/DIABLO) and
inhibitor of IAPs (Inhibitor of Apoptosis Proteins), with potential antineoplastic
activity. Upon administration, Smac mimetic BI 891065 targets and binds to the Smac
binding groove on IAPs, including the caspase inhibitor X chromosome-linked IAP (XIAP)
and the cellular IAPs 1 and 2. This inhibits the activities of these IAPs and promotes
the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed
by many cancer cell types and suppress apoptosis by binding to and inhibiting certain
caspases.;
UNII : XE77D7FKW4;
CAS number : 1875100-07-4;
Molecule name : BI 891065;
NCI Metathesaurus CUI : CL552291;
Origin ID : C150507;
UMLS CUI : C4725787;
Semantic type(s)
- concept_is_in_subset
- has_target
