B-Cell Survival Pathway

Preferred Label : B-Cell Survival Pathway;

NCIt related terms : B Cell Survival Pathway;

Alternative definition : BIOCARTA: Physical interactions between integrin alpha4beta1 heterodimer expressed on B cells and counter receptors on stroma cells are key mediators of the survival of normal and malignant B cells. Recent data indicate that integrin stimulation increases FBI-1, XIAP, survivin, and CCT4 expression but inhibits Requiem, c-Fos, and caspase 3 and 7 induction. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_bcellsurvivalPathway;

Details

Origin ID

C39004;

UMLS CUI

C1511005;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- 3-Phosphoinositide-Dependent Protein Kinase 1 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 5 [NCIt concept]
- Caspase-3 [NCIt concept]
- Caspase-7 [NCIt concept]
- E3 Ubiquitin-Protein Ligase XIAP [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Proto-Oncogene c-Fos [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
- Transcription Factor Jun-D [NCIt concept]
- Zinc Finger Protein Ubi-D4 [NCIt concept]
- Zinc Finger and BTB Domain-Containing Protein 7A [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- BIRC5 wt Allele [NCIt concept]
- CASP3 wt Allele [NCIt concept]
- CASP7 wt Allele [NCIt concept]
- DPF2 wt Allele [NCIt concept]
- FOS wt Allele [NCIt concept]
- JUND wt Allele [NCIt concept]
- MTOR wt Allele [NCIt concept]
- PDPK1 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- XIAP wt Allele [NCIt concept]
- ZBTB7A wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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