XIAP wt Allele

Preferred Label : XIAP wt Allele;

NCIt synonyms : ILP; MIHA; API3; X-Linked Inhibitor of Apoptosis wt Allele; Baculoviral IAP Repeat-Containing 4 Gene; BIRC4; BIRC4 wt Allele;

NCIt definition : Human XAIP wild-type allele is located in the vicinity of Xq25 and is approximately 54 kb in length. This allele, which encodes baculoviral IAP repeat-containing protein 4, is involved in anti-apoptotic activities through caspase inhibition.;

NCIt note : Similarly to BIRC2, BIRC4 inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. BIRC4 also specifically inhibits two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. A novel transcript homologous to BIRC4 is expressed solely in the testis. The protein encoded by this gene is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2.;

GenBank Accession Number : NM_001167;

Details

Origin ID

C49358;

UMLS CUI

C1706587;

False automatic mappings
- Inductive Machine Learning [EFMI term]
OMIM relation
- Inhibitor of apoptosis, X-linked [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- X: 122719583-122773357 [NCIt concept]
gene_in_chromosomal_location
- Xq25 [NCIt concept]
gene_is_element_in_pathway
- B-Cell Survival Pathway [NCIt concept]
- Caspase Cascade Pathway [NCIt concept]
- Mitochondria in Apoptotic Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Apoptosis [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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