CASP7 wt Allele

Preferred Label : CASP7 wt Allele;

NCIt synonyms : Apoptotic Protease MCH-3 Gene; Caspase 7, Apoptosis-Related Cysteine Protease wt Allele; Caspase-7 Gene; CMH-1; MCH3; ICE-LAP3 Gene; ICE-Like Apoptotic Protease 3 Gene; Caspase 7 Gene;

NCIt definition : Human CASP7 wild-type allele is located within 10q25 and is approximately 52 kb in length. This allele, which encodes caspase-7 protein, is involved in apoptosis via the cleavage and activation of both sterol regulatory element binding proteins and poly (ADP-ribose) polymerase (PARP). Overexpression of the CASP7 gene promotes programmed cell death. Loss of heterozygosity of the CASP7 gene has been detected in several types of solid tumors.;

GenBank Accession Number : NM_033339;

Details

Origin ID

C49559;

UMLS CUI

C1704796;

OMIM relation
- Caspase 7, apoptosis-related cysteine protease [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 7: 115428952-115480652 [NCIt concept]
gene_in_chromosomal_location
- 10q25 [NCIt concept]
gene_is_element_in_pathway
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Apoptosis DNA Damage Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Apoptotic DNA Fragmentation Pathway [NCIt concept]
- B-Cell Survival Pathway [NCIt concept]
- Caspase Cascade Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
- E2F Transcription Factor Pathway [NCIt concept]
- Fas Signaling Pathway BioCarta [NCIt concept]
- HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- Mitochondria in Apoptotic Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Apoptosis [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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