" /> Tolinapant - CISMeF





Preferred Label : Tolinapant;

NCIt synonyms : XIAP/cIAP1 Antagonist ASTX660;

NCIt definition : An orally bioavailable, non-peptidomimetic antagonist of both X chromosome-linked inhibitor of apoptosis protein (XIAP) and cellular IAP 1 (cIAP1), with potential antineoplastic and pro-apoptotic activities. Upon administration, tolinapant selectively binds to and inhibits the activity of XIAP and cIAP1. This restores and promotes the induction of apoptotic signaling pathways in cancer cells, and inactivates the nuclear factor-kappa B (NF-kB)-mediated survival pathway. XIAP and cIAP1 are overexpressed by many cancer cell types and suppress apoptosis by inhibiting the activity of certain caspases; they promote both cancer cell survival and chemotherapy resistance.;

UNII : 2LHZ9ZC3YO;

CAS number : 1799328-86-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1799328-86-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ASTX 660; ASTX660;

NCI Metathesaurus CUI : CL498277;

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12/05/2024


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