NCIt definition : A second-generation synthetic antisense oligonucleotide with potential antineoplastic
activity. AEG35156 selectively blocks the cellular expression of X-linked inhibitor
of apoptosis protein (XIAP), a pivotal inhibitor of apoptosis that is overexpressed
in many tumors. This agent reduces total levels of XIAP in tumor cells, working synergistically
with cytotoxic drugs to overcome tumor cell resistance to apoptosis. XIAP interferes
with both the intrinsic and extrinsic program-death signaling pathways, which may
render tumor cells resistant to apoptosis.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. AEG35156 may kill
cancer cells by blocking the production of a protein called XIAP that helps cells
live longer. It also makes cancer cells more sensitive to anticancer drugs. It is
a type of antisense oligonucleotide, and a type of chemosensitizing agent.;
UNII : T4V3YL9QHU;
CAS number : 928841-57-0;
Drug name : GEM640;
Molecule name : AEG-35156; AEG 35156;
Codes from synonyms : CDR0000539480; CDR0000518310;