XIAP Antisense Oligonucleotide AEG35156

Preferred Label : XIAP Antisense Oligonucleotide AEG35156;

NCIt related terms : AEG35156; GEM640;

NCIt definition : A second-generation synthetic antisense oligonucleotide with potential antineoplastic activity. AEG35156 selectively blocks the cellular expression of X-linked inhibitor of apoptosis protein (XIAP), a pivotal inhibitor of apoptosis that is overexpressed in many tumors. This agent reduces total levels of XIAP in tumor cells, working synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. XIAP interferes with both the intrinsic and extrinsic program-death signaling pathways, which may render tumor cells resistant to apoptosis.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. AEG35156 may kill cancer cells by blocking the production of a protein called XIAP that helps cells live longer. It also makes cancer cells more sensitive to anticancer drugs. It is a type of antisense oligonucleotide, and a type of chemosensitizing agent.;

Drug name : GEM640;

Codes from synonyms : CDR0000539480; CDR0000518310;

Details

Origin ID

C49180;

UMLS CUI

C1567121;

Currated CISMeF NLP mapping
- AEG 35156 [MeSH Supplementary Concept]
- AEG 35156 [MeSH concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- AEG 35156 [MeSH concept]
- AEG 35156 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- E3 Ubiquitin-Protein Ligase XIAP [NCIt concept]

Keyword's position in hierarchy(ies) :

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