Preferred Label : Dasminapant;
NCIt synonyms : SMAC-mimetic APG-1387; IAP Antagonist APG-1387; Pyrrolo(1,2-a)(1,5)diazocine-8-carboxamide, 3,3'-(1,3-phenylenebis(sulfonyl))bis(N-(diphenylmethyl)decahydro-5-(((2S)-2-(methylamino)-1-oxopropyl)amino)-6-oxo-,
(5S,5'S,8S,8'S,10aR,10'ar)-; IAP Inhibitor APG-1387;
NCIt definition : A small molecule, second mitochondria-derived activator of caspases (SMAC)-mimetic
targeting inhibitor of apoptosis proteins (IAPs) with potential apoptosis-inducing
and antineoplastic activities. Upon administration, dasminapant selectively binds
to and inhibits the activity of IAPs including X chromosome-linked IAP (XIAP) and
cellular IAPs 1 (c-IAP1) and 2 (c-IAP2). This may restore and promote the induction
of apoptosis through apoptotic signaling pathways and enhance proteasomal degradation
of IAPs. Additionally, dasminapant may work synergistically with cytotoxic drugs to
overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer
cell types, suppressing apoptosis by binding and inhibiting active caspases-3, -7
and -9 via their BIR (baculoviral lAP repeat) domains.;
UNII : E53VN70K2X;
InChIKey : AKLBERUGKZNEJY-RTEPGWBGSA-N;
CAS number : 1570231-89-8;
Molecule name : APG 1387; SM-1387; APG-1387;
NCI Metathesaurus CUI : CL971113;
Origin ID : C162535;
UMLS CUI : C5207019;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
