Preferred Label : IAP Inhibitor HGS1029;
NCIt definition : The hydrochloride salt of a small-molecule inhibitor of IAP (Inhibitor of Apoptosis
Protein) family proteins with potential antineoplastic activity. IAP inhibitor HGS1029
selectively inhibits the biological activity of IAP proteins, which may restore apoptotic
signaling pathways; this agent may work synergistically with cytotoxic drugs to overcome
tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types,
suppressing apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their
BIR (baculoviral lAP repeat) domains.;
Molecule name : HGS1029; AEG40826-2HCl;
NCI Metathesaurus CUI : CL387473;
Origin ID : C78484;
UMLS CUI : C2697640;
Semantic type(s)
- concept_is_in_subset
- has_target
