Preferred Label : Survivin-targeted Vaccine OVM-200;
NCIt synonyms : Survivin Recombinant Overlapping Peptides Vaccine OVM-200; Survivin-targeting Cancer Vaccine OVM-200; Survivin ROPs Vaccine OVM-200; Survivin Peptides Vaccine OVM-200;
NCIt definition : A cancer vaccine consisting of recombinant overlapping peptides (ROPs) derived from
the anti-apoptosis protein survivin, with potential immunopotentiating and antineoplastic
activities. Upon administration, survivin-targeted vaccine OVM-200 may stimulate the
immune system to mount a cytotoxic T-lymphocyte (CTL) response against survivin-expressing
tumor cells, resulting in decreased tumor cell proliferation and tumor cell death.
The survivin protein inhibits caspase activation and apoptosis; it is undetectable
in normal adult tissues but is expressed by several human cancers including lung,
colon, breast, pancreas, and prostate cancer as well as hematopoietic malignancies
and skin cancers.;
Molecule name : OVM-200; OVM 200;
NCI Metathesaurus CUI : CL1773506;
Origin ID : C185161;
UMLS CUI : C5666954;
Semantic type(s)
- concept_is_in_subset
- has_target
