Ad5-survivin-transduced Autologous Dendritic Cell Vaccine

Preferred Label : Ad5-survivin-transduced Autologous Dendritic Cell Vaccine;

NCIt synonyms : Autologous Dendritic Cell Adenovirus Type 5-Survivin Vaccine; Autologous DC:AdmS; Ad5-survivin-transduced Autologous DC Vaccine;

NCIt definition : A cell-based cancer vaccine containing autologous dendritic cells (DCs) that are transduced with a replication-deficient adenovirus type 5 vector (Ad5) encoding a mutated form of the tumor-associated antigen (TAA) survivin, with potential immunostimulatory and antineoplastic activities. Upon administration, Ad5-survivin-transduced autologous DC vaccine may elicit an immune response against cancer cells expressing survivin by activating cytotoxic T-cells (CTLs). This leads to an induction of cell death in survivin-positive tumor cells. Survivin, a member of the inhibitor of apoptosis (IAP) family of proteins, may be upregulated in certain tumor cell types and plays a key role in tumor cell growth and survival.;

NCI Metathesaurus CUI : CL512260;

Details

Origin ID

C128860;

UMLS CUI

C4289997;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Baculoviral IAP Repeat-Containing Protein 5 [NCIt concept]

Keyword's position in hierarchy(ies) :

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