Preferred Label : HLA-A2-restricted IL-13Ra2/EphA2/Survivin/Tetanus Toxoid T-helper Epitopes-Montanide
51 Vaccine;
NCIt synonyms : HLA-A2-restricted IL-13Ra2/EphA2/Survivin/Tetanus Toxoid T-helper Peptides-Montanide
51 Vaccine;
NCIt definition : A peptide vaccine comprised of synthetic human leukocyte antigen (HLA)-A2-restricted
peptides derived from the tumor-associated antigens (TAAs) interleukin-13 receptor
alpha-2 (IL-13Ra2), the tyrosine kinase receptor Ephrin receptor A2 (EphA2), and the
apoptosis inhibitor protein survivin, combined with the adjuvant tetanus toxoid (TT)-derived
helper T-cell peptide, and emulsified in the immunoadjuvant Montanide ISA-51, with
potential immunostimulating and antineoplastic activities. Specifically, this vaccine
contains the epitopes: IL-13Ralpha2 345-353:1A9V, which is an engineered peptide based
on amino acids 345-353 of IL-13Ra2 where the amino acids at the first and ninth positions
of the peptide have been replaced with alanine and valine, respectively, EphA2 883-891,
and survivin 96-104. Upon administration, the HLA-A2-restricted IL-13Ra2/EphA2/survivin/TT
T-helper epitopes-Montanide 51 vaccine may stimulate a HLA-A2-restricted cytotoxic
T-lymphocyte (CTL) response against tumor cells that overexpress IL-13Ra2, EphA2,
or survivin, and results in tumor cell lysis. TT T-helper peptide binds to class II
major histocompatibility molecules (MHC) molecules as a nonspecific vaccine helper
epitope, resulting in long-term immunopotentiation by increasing the helper T-cell
response. Montanide ISA-51, a stabilized water-in-oil emulsion adjuvant containing
mineral oil with mannide monooleate added as a surfactant, non-specifically stimulates
cell-mediated immune responses to antigens. IL-13Ra2, EphA2 and survivin, TAAs that
are overexpressed in certain tumor cell types, play key roles in tumor cell proliferation.
HLA-A2 presents antigenic peptides to CD8 T-cells; epitope design restricted to epitopes
that bind most efficiently to HLA-A2 may improve peptide immunogenicity.;
NCI Metathesaurus CUI : CL509616;
Origin ID : C128562;
UMLS CUI : C4289010;
Semantic type(s)
- concept_is_in_subset
- has_target
