NCIt synonyms : Adenocarcinoma of Prostate; Adenocarcinoma of the Prostate; PRAD;
NCIt definition : An adenocarcinoma arising from the prostate gland. It is one of the most common malignant
tumors afflicting men. The majority of adenocarcinomas arise in the peripheral zone
and a minority occurs in the central or the transitional zone of the prostate gland.
Grading of prostatic adenocarcinoma predicts disease progression and correlates with
survival. Several grading systems have been proposed, of which the Gleason system
is the most commonly used. Gleason sums of 2 to 4 represent well-differentiated disease,
5 to 7 moderately differentiated disease and 8 to 10 poorly differentiated disease.
Prostatic-specific antigen (PSA) serum test is widely used as a screening test for
the early detection of prostatic adenocarcinoma. Treatment options include radical
prostatectomy, radiation therapy, androgen ablation and cryotherapy. Watchful waiting
or surveillance alone is an option for older patients with low-grade or low-stage
disease.;