" /> TMPRSS2/ERG Fusion Gene - CISMeF





Preferred Label : TMPRSS2/ERG Fusion Gene;

NCIt synonyms : TMPRSS2-ERG Fusion Gene; ERG/TMPRSS2 Fusion Gene; T2:ERG; Transmembrane Protease, Serine 2/V-Ets Erythroblastosis Virus E26 Oncogene Homolog (Avian) Fusion Gene; TMPRSS2::ERG Fusion Gene;

NCIt definition : A fusion gene that results from a genetic translocation event which fuses the 5' end of the androgen-regulated TMPRSS2 gene with the entire coding region of the ERG gene. The androgen-dependent expression of this fusion gene results in overexpression of ERG activity.;

NCIt note : This gene fusion was the first ever discovered in a solid tumor. It is also a biomarker for Prostate Cancer. 7 October, NCI Cancer Bulletin 5, 20 (2008);

NCI Metathesaurus CUI : CL448906;

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30/04/2024


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