Prostatic Intraepithelial Neoplasia-Like Adenocarcinoma

Preferred Label : Prostatic Intraepithelial Neoplasia-Like Adenocarcinoma;

NCIt synonyms : PIN-Like Adenocarcinoma;

NCIt definition : A rare subtype of prostate acinar adenocarcinoma that morphologically resembles high-grade prostatic intraepithelial neoplasia. It is characterized by the presence of large malignant glands lined with pseudostratified epithelium. It is graded as Gleason score 3 3 6.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1905417;

Details

Origin ID

C191961;

UMLS CUI

C5787271;

Disease excludes abnormal cell
- Malignant Squamous Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
Disease may have findings
- Perineural Invasion [NCIt concept]
- Prostatic Crystalloids Present [NCIt concept]
- Serum Prostate Specific Antigen Increased [NCIt concept]
- Urinary Retention [NCIt concept]
Has associated anatomic sites
- Genitourinary System [NCIt concept]
- Male Reproductive System [NCIt concept]
- Prostate Gland [NCIt concept]
- Reproductive System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
disease_has_abnormal_cell
- Adenocarcinoma Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Neoplastic Acinar Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
- Secretory Adenocarcinoma Cell [NCIt concept]
disease_has_finding
- Absence of Basal Cell Layer [NCIt concept]
- Acinar Cell Differentiation [NCIt concept]
- Carcinomatous Component Present [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Invasive Lesion [NCIt concept]
- Large Malignant Glands Lined with Pseudostratified Epithelium Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_normal_cell_origin
- Acinar Cell [NCIt concept]
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Glandular Epithelium [NCIt concept]
- Prostatic Epithelium [NCIt concept]
disease_has_primary_anatomic_site
- Genitourinary System [NCIt concept]
- Male Reproductive System [NCIt concept]
- Prostate Gland [NCIt concept]
disease_mapped_to_gene
- ERG Gene [NCIt concept]
- TMPRSS2/ERG Fusion Gene [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 18q [NCIt concept]
- Gain of Chromosome 1q [NCIt concept]
- Gain of Chromosome 2p [NCIt concept]
- Gain of Chromosome 7 [NCIt concept]
- Gain of Chromosome 8q [NCIt concept]
- Gain of Chromosome Xq [NCIt concept]
- Loss of Chromosome 10q [NCIt concept]
- Loss of Chromosome 13q [NCIt concept]
- Loss of Chromosome 16q [NCIt concept]
- Loss of Chromosome 18q [NCIt concept]
- Loss of Chromosome 1p [NCIt concept]
- Loss of Chromosome 6p [NCIt concept]
- Loss of Chromosome 8p [NCIt concept]
disease_may_have_molecular_abnormality
- ERG Gene Rearrangement [NCIt concept]
- PTEN Gene Inactivation [NCIt concept]
- TMPRSS2-ERG Fusion Protein Expression [NCIt concept]
- TP53 Gene Inactivation [NCIt concept]

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