NCIt definition : A cancer vaccine comprised of 11 peptides associated with glioblastoma multiforme
(GBM), with potential immunomodulating and antineoplastic activities. Vaccination
with glioblastoma multiforme multi-antigen vaccine IMA950 stimulates the host immune
system to mount a cytotoxic T-lymphocyte (CTL) response as well as a T-helper (Th)
immune response against tumor cells expressing these peptides, potentially resulting
in decreased tumor growth of GBM. Peptides in IMA950 consist of the following: brevican
(BCAN); chondroitin sulfate proteoglycan 4 (CSPG4); fatty acid binding protein 7,
brain (FABP7); insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3); neuroligin
4, X-linked (NLGN4X); neuronal cell adhesion molecule (NRCAM); protein tyrosine phosphatase,
receptor-type, Z polypeptide 1 (PTPRZ1); tenascin C (TNC); Met proto-oncogene (MET);
baculoviral IAP repeat-containing 5 (BIRC5); and hepatitis B virus core antigen.;