Tenascin - CISMeF

Preferred Label : Tenascin;

NCIt synonyms : Hexabrachion; Cytotactin; TNC; Neuronectin; GMEM; TN-C; Glioma-Associated-Extracellular Matrix Antigen; Myotendinous Antigen; TN; GP 150-225; JI; Tenascin C; Tenascin-C;

NCIt definition : Tenascin (2201 aa, 241 kDa) is encoded by the human TNC gene. This protein is involved in neuron migration and axon guidance.;

NCIt note : Tenascin (hexabrachion, cytotactin) is an extracellular matrix protein that promotes cell attachment with spatially and temporally restricted tissue distribution in many developing organs. It is a hexameric, multidomain protein with disulfide-linked subunits. A C-terminal domain is similar to fibrinogen. Tenascin also contains type III units, similar to those in fibronectin, and EGF-like repeats. In the CNS, tenascin C is expressed primarily by astrocytes. Tenascin expression is induced by serum as well as TGF-beta.; Hexameric extracellular matrix glycoprotein transiently expressed in many developing organs and often re-expressed in tumors. It is present in the central and peripheral nervous systems as well as in smooth muscle and tendons.;

Details

Origin ID

C17338;

UMLS CUI

C0068613;

Currated CISMeF NLP mapping
- tenacin [MeSH concept]
- tenacin [MeSH Supplementary Concept]
OMIM relation
- Tenascin C [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- neuronectin [MeSH concept]
- neuronectin [MeSH Supplementary Concept]
gene_encodes_gene_product
- Extracellular Matrix Protein Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
- TNC Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Tenatumomab [NCIt concept]
gene_product_expressed_in_tissue
- Astrocyte [NCIt concept]
- Keratinocyte [NCIt concept]
- Periosteum [NCIt concept]
- Smooth Muscle Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Matrix [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
- Tenascin Family [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
gene_product_is_element_in_pathway
- ECM-Receptor Interaction Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Movement [NCIt concept]
- Environment-to-Cell Communication [NCIt concept]
- Morphogenesis [NCIt concept]
- Organogenesis [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Wound Repair [NCIt concept]
is_target
- Glioblastoma Multiforme Multipeptide Vaccine IMA950 [NCIt concept]
- Iodine I 131 Monoclonal Antibody 81C6 [NCIt concept]

Keyword's position in hierarchy(ies) :

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