NCIt definition : Tenascin (2201 aa, 241 kDa) is encoded by the human TNC gene. This protein is involved
in neuron migration and axon guidance.;
NCIt note : Tenascin (hexabrachion, cytotactin) is an extracellular matrix protein that promotes
cell attachment with spatially and temporally restricted tissue distribution in many
developing organs. It is a hexameric, multidomain protein with disulfide-linked subunits
that is transiently expressed in many developing organs and often re-expressed in
tumors. It is present in the central and peripheral nervous systems as well as in
smooth muscle and tendons. The C-terminal domain of tenascin is similar to fibrinogen;
the protein also contains type III units, similar to those in fibronectin, and EGF-like
repeats.;