Neuronal Cell Adhesion Molecule

Preferred Label : Neuronal Cell Adhesion Molecule;

NCIt synonyms : Nr-CAM; hBravo; NgCAM-Related Cell Adhesion Molecule; NRCAM; Bravo; Ng-CAM-Related; Neuronal Surface Protein Bravo;

NCIt definition : Neuronal cell adhesion molecule (1304 aa, 144 kDa) is encoded by the human NRCAM gene. This protein plays a role in both neuronal development and neuron-neuron adhesion.;

NCIt note : Neuronal cell adhesion molecule is an ankyrin-binding, potential type I membrane protein involved in neuron-neuron adhesion and containing 5 fibronectin type III domains and 6 Ig-like C2-type domains. A likely constituent of a neurofascin/NRCAM/ankyrin G complex, NRCAM may play a role in development of the nervous system. Vertebrate and invertebrate cell adhesion molecules in the nervous system are usually cell surface membrane proteins with multiple N-terminal Ig domains, followed by several fibronectin type III repeats, and either a transmembrane intracellular domain or a C-terminal glycophosphatidylinositol-linked membrane anchor.;

Details

Origin ID

C34001;

UMLS CUI

C1314772;

Currated CISMeF NLP mapping
- Bravo (qualifier value) [SNOMED CT concept]
- bravo [MeSH concept]
- cell adhesion molecules, neuronal [MeSH Descriptor]
- cell adhesion molecules, neuronal [MeSH concept]
OMIM relation
- Neuronal cell adhesion molecule [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- NRCAM protein, human [MeSH concept]
- NRCAM protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Cell Adhesion Molecule Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- NRCAM Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Neural Development [NCIt concept]
- Regulation of Cell Shape [NCIt concept]
is_target
- Glioblastoma Multiforme Multipeptide Vaccine IMA950 [NCIt concept]

Keyword's position in hierarchy(ies) :

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