Gataparsen Sodium

Preferred Label : Gataparsen Sodium;

NCIt synonyms : Antisurvivin Antisense Oligonucleotide LY2181308; LY2181308 Heptadecasodium Salt;

NCIt definition : A second-generation antisense oligonucleotide against survivin mRNA with potential antitumor activity. Gataparsen hybridizes to survivin mRNA, thereby blocking translation of survivin protein, a member of the inhibitor of apoptosis (IAP) family. Survivin, expressed during embryonal development, is upregulated in a variety of human cancers while absent in most normal adult cells; its expression in tumors is associated with a more aggressive phenotype, shorter survival times, and a decreased response to chemotherapy. Silencing expression of survivin potentially leads to restoration of the apoptotic process in cancer cells, thereby facilitating chemotherapeutic treatments.;

UNII : 3KY0EUQ36S;

CAS number : 928768-71-2;

Molecule name : LY-2181308; LY 2181308;

Details

Origin ID

C66935;

UMLS CUI

C2980073;

Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Baculoviral IAP Repeat-Containing Protein 5 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- RNA Binding [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Apoptosis [NCIt concept]
- Translational Repression [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Baculoviral IAP Repeat-Containing Protein 5 [NCIt concept]

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