NCIt definition : A second-generation antisense oligonucleotide against survivin mRNA with potential
antitumor activity. Gataparsen hybridizes to survivin mRNA, thereby blocking translation
of survivin protein, a member of the inhibitor of apoptosis (IAP) family. Survivin,
expressed during embryonal development, is upregulated in a variety of human cancers
while absent in most normal adult cells; its expression in tumors is associated with
a more aggressive phenotype, shorter survival times, and a decreased response to chemotherapy.
Silencing expression of survivin potentially leads to restoration of the apoptotic
process in cancer cells, thereby facilitating chemotherapeutic treatments.;
UNII : 3KY0EUQ36S;
CAS number : 928768-71-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 928768-71-2
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