NCIt definition : A lipid depot-based therapeutic cancer vaccine composed of survivin epitopes, a universal
T Helper peptide and a polynucleotide adjuvant encapsulated in liposomes and then
formulated in the hydrophobic carrier Montanide ISA51 VG, with potential immunopotentiating
and antineoplastic activities. Upon injection of Maveropepimut-S, a depot is created
at the injection site from which the antigens and adjuvant are released. This vaccine
may elicit a long lasting cellular response against survivin-expressing cancers, resulting
in a decrease in tumor cell proliferation and an induction of tumor cell death. Survivin,
a member of the inhibitor of apoptosis (IAP) family expressed during embryonic development,
is upregulated in a variety of human cancers while absent in most normal adult cells;
its expression in tumors is associated with a more aggressive phenotype, decreased
survival, and increased resistance to chemotherapy.;
Semantic type(s)