Preferred Label : Patient-derived WT1/PRAME/Survivin-specific Cytotoxic T-lymphocytes;
NCIt synonyms : TAATs; Autologous Tumor Antigen Associated Cytotoxic T-Lymphocytes; Patient-derived Multi-antigen Associated Cytotoxic T-lymphocytes; TAA-T; Patient-derived WT1/PRAME/Survivin-specific T-lymphocytes;
NCIt definition : A preparation of autologous cytotoxic T-lymphocytes (CTLs) specifically reactive to
the tumor associated antigens (TAAs) human Wilms tumor protein (WT1), preferentially
expressed antigen of melanoma (PRAME, melanoma antigen preferentially expressed in
tumors; Opa-interacting protein 4), and survivin (baculoviral IAP repeat-containing
protein 5), with potential antineoplastic activities. Upon collection, expansion,
and stimulation with antigen presenting cells pulsed with an overlapping peptide library
spanning the TAAs, the multi-antigen associated CTLs are re-introduced into the patient
and may induce a CTL-mediated response against tumor cells expressing WT1, PRAME,
or survivin, potentially leading to tumor cell lysis and inhibition of tumor cell
proliferation. WT1, PRAME, and survivin, are expressed on certain tumor cell types
and play key role in tumor cell proliferation and survival.;
NCI Metathesaurus CUI : CL971022;
Origin ID : C162624;
UMLS CUI : C5206702;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
