Preferred Label : Survivin-expressing CVD908ssb-TXSVN Vaccine;
NCIt synonyms : Salmonella-based Survivin Vaccine CVD908ssb-TXSVN;
NCIt definition : An orally bioavailable Salmonella-based survivin vaccine composed of a weakened form
of a live strain of Salmonella bacteria (CVD908ssb strain) that has been genetically
modified to produce the tumor-associated antigen (TAA) survivin, with potential immunopotentiating
and antineoplastic activities. Upon administration of the CVD908ssb-TXSVN vaccine,
the expressed survivin stimulates the immune response to elicit a cytotoxic T-lymphocyte
(CTL)-mediated immune response against survivin-expressing cancer cells, resulting
in a decrease in tumor cell proliferation and an induction of tumor cell death. Survivin,
a member of the inhibitor of apoptosis (IAP) family expressed during embryonic development,
is upregulated in a variety of human cancers while absent in most normal adult cells;
its expression in tumors is associated with a more aggressive phenotype, decreased
survival, and increased resistance to chemotherapy.;
Molecule name : TXSVN; CVD908ssb-TXSVN;
NCI Metathesaurus CUI : CL938073;
Origin ID : C158607;
UMLS CUI : C4764292;
Semantic type(s)
- concept_is_in_subset
- has_target
