Preferred Label : Sepantronium Bromide;
NCIt synonyms : 1H-Naphth(2,3-d)imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazinylmethyl)-,
Bromide; Survivin Inhibitor YM155; YM155;
NCIt definition : A small-molecule proapoptotic agent with potential antineoplastic activity. Sepantronium
bromide selectively inhibits survivin expression in tumor cells, resulting in inhibition
of survivin antiapoptotic activity (via the extrinsic or intrinsic apoptotic pathways)
and tumor cell apoptosis. Survivin, a member of the inhibitor of apoptosis (IAP) gene
family, is expressed during embryonal development and is absent in most normal, terminally
differentiated tissues; upregulated in a variety of human cancers, its expression
in tumors is associated with a more aggressive phenotype, shorter survival times,
and a decreased response to chemotherapy.;
UNII : 7H5Q4J1CM5;
InChIKey : QBIYUDDJPRGKNJ-UHFFFAOYSA-M;
CAS number : 781661-94-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 781661-94-7
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : YM-155;
Chemical formula : C20H19N4O3.Br;
Origin ID : C61091;
UMLS CUI : C2980068;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
