Preferred Label : WT1/PRAME/Survivin-specific Cytotoxic T-lymphocytes;
NCIt synonyms : WT1/PRAME/Survivin-specific CTLs;
NCIt definition : A preparation of cytotoxic T-lymphocytes (CTLs) specifically reactive to the tumor-associated
antigens (TAAs) human Wilms tumor protein (WT1), preferentially expressed antigen
of melanoma (PRAME; melanoma antigen preferentially expressed in tumors; Opa-interacting
protein 4; OIP-4), and survivin (baculoviral IAP repeat-containing protein 5; BIRC5),
with potential immunomodulating and antineoplastic activities. Upon collection of
peripheral blood mononuclear cells (PBMCs), these cells are stimulated with antigen
presenting cells (APCs) pulsed with WT1, PRAME and survivin peptides; reactive T-cells
are selectively expanded. Upon administration of the WT1/PRAME/Survivin-specific CTLs,
these T-cells induce a CTL-mediated response against tumor cells expressing WT1, PRAME,
or survivin, leading to tumor cell lysis and inhibition of tumor cell proliferation.
WT1, PRAME, and survivin, are expressed on certain tumor cell types and play key roles
in tumor cell proliferation and survival.;
NCI Metathesaurus CUI : CL973212;
Origin ID : C162764;
UMLS CUI : C5206807;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
