Autologous HPV16/HPV18/Survivin-specific CD8 T-cells NEXI-003

Preferred Label : Autologous HPV16/HPV18/Survivin-specific CD8 T-cells NEXI-003;

NCIt synonyms : Autologous HPV Tumor-relevant Antigen-specific CD8 T-cells NEXI-003; CD3 CD4- CD8 T-cells NEXI-003;

NCIt definition : A preparation of autologous CD3 CD4- CD8 T-cells targeting multiple human papilloma virus (HPV) tumor-associated antigens, including HPV types 16 and 18 antigens and survivin, with potential immunomodulating and antineoplastic activities. Following leukapheresis and ex vivo priming and expansion, the autologous HPV16/HPV18/survivin-specific CD8 T-cells NEXI-003 are re-introduced into the patient, where they target and kill tumor cells expressing these HPV tumor-associated antigens.;

Molecule name : NEXI-003; NEXI 003;

NCI Metathesaurus CUI : CL1912860;

Details

Origin ID

C192801;

UMLS CUI

C5785424;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Baculoviral IAP Repeat-Containing Protein 5 [NCIt concept]

Keyword's position in hierarchy(ies) :

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