NCIt definition : A synthetic peptide vaccine consisting of a HLA-A24-restricted human Wilms' Tumor
protein-1 (WT1) peptide comprised of amino acids 235 through 243, a MHC class I-restricted
peptide, with potential immunomodulating and antitumor activities. Vaccination with
WT1 235-243 peptide may induce a WT1-specific cytotoxic T-lymphocyte (CTL) response
against WT1 expressing cells, resulting in cell lysis and inhibition of cancer cell
proliferation. WT1, a zinc finger DNA-binding protein, is overexpressed in most types
of leukemia and in a variety of solid cancers.;
Semantic type(s)