Transcription Factor Sp1

Preferred Label : Transcription Factor Sp1;

NCIt synonyms : SP1; Stimulatory Protein 1; Sp1 Transcription Factor;

NCIt definition : Transcription factor Sp1 (785 aa, 80 kDa) is encoded by the human SP1 gene. This protein plays a role in the regulation of gene expression.;

NCIt note : Transcription factor SP1 is a DNA-binding protein that interacts with various RNA polymerase II gene promoters containing GC-box elements. It has contiguous zinc finger motifs and requires zinc for sequence-specific binding to DNA. The formation of head segments in Drosophila depends on the homologue of the human transcription factor SP1. (from OMIM 189906);

Details

Origin ID

C20637;

UMLS CUI

C1308232;

Currated CISMeF NLP mapping
- Sp1 transcription factor [MeSH concept]
- sp1 transcription factor [MeSH Descriptor]
OMIM relation
- Transcription factor sp1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Sp1 protein, human [MeSH concept]
- Sp1 protein, human [MeSH Supplementary Concept]
- Sp1 transcription factor [MeSH concept]
- sp1 transcription factor [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- SP1 Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- C2H2 Zinc Finger [NCIt concept]
gene_product_is_element_in_pathway
- Agrin Pathway [NCIt concept]
- Calcineurin Pathway [NCIt concept]
- E2F Transcription Factor Pathway [NCIt concept]
- FOXA1 Transcription Factor Signaling Pathway [NCIt concept]
- FOXA2 and FOXA3 Transcription Factor Signaling Pathway [NCIt concept]
- FOXM1 Transcription Factor Signaling Pathway [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- HIF-2-Alpha Transcription Factor Pathway [NCIt concept]
- Human Cytomegalovirus Infection Pathway [NCIt concept]
- Huntington's Disease Pathway [NCIt concept]
- IL2/STAT5 Signaling Pathway [NCIt concept]
- IL4-Mediated Signaling Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- PPAR-alpha Gene Regulation Pathway [NCIt concept]
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
- Telomerase Regulation Pathway [NCIt concept]
- Terc Regulation Pathway [NCIt concept]
- Tert Regulation Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients