Cellular Tumor Antigen p53

Preferred Label : Cellular Tumor Antigen p53;

NCIt synonyms : Tumor Protein p53; p53 Tumor Suppressor; Phosphoprotein P53; Tumor Suppressor p53; Antigen NY-CO-13; P53 Protein; Tumor Protein-p53; TP53; Transformation-Related Protein 53;

NCIt related terms : p53;

NCIt definition : Cellular tumor antigen p53 (393 aa, 44 kDa) is encoded by the human TP53 gene. This protein plays a role in the regulation of both the cell cycle and apoptosis.;

Details

Origin ID

C17387;

UMLS CUI

C0146283;

OMIM relation
- Tumor protein p53 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TP53 protein, human [MeSH Supplementary Concept]
- TP53 protein, human [MeSH concept]
concept_is_in_subset
- CPTAC Baseline Medical Forms Terminology [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CPTAC Uterine Corpus Endometrial Carcinoma Baseline Form [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- TP53 Gene [NCIt concept]
gene_product_has_biochemical_function
- 3'-5' Exonuclease [NCIt concept]
- DNA Binding Protein [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_gene_product_variant
- TP53 NP_000537.3:p.C238Y [NCIt concept]
- TP53 NP_000537.3:p.G245D [NCIt concept]
- TP53 NP_000537.3:p.G245S [NCIt concept]
- TP53 NP_000537.3:p.G266E [NCIt concept]
- TP53 NP_000537.3:p.G266V [NCIt concept]
- TP53 NP_000537.3:p.G302 Frameshift [NCIt concept]
- TP53 NP_000537.3:p.K132E [NCIt concept]
- TP53 NP_000537.3:p.K132N [NCIt concept]
- TP53 NP_000537.3:p.P250L [NCIt concept]
- TP53 NP_000537.3:p.R175C [NCIt concept]
- TP53 NP_000537.3:p.R175H [NCIt concept]
- TP53 NP_000537.3:p.R181H [NCIt concept]
- TP53 NP_000537.3:p.R213L [NCIt concept]
- TP53 NP_000537.3:p.R213Q [NCIt concept]
- TP53 NP_000537.3:p.R248Q [NCIt concept]
- TP53 NP_000537.3:p.R248W [NCIt concept]
- TP53 NP_000537.3:p.R249M [NCIt concept]
- TP53 NP_000537.3:p.R273C [NCIt concept]
- TP53 NP_000537.3:p.R273H [NCIt concept]
- TP53 NP_000537.3:p.R273L [NCIt concept]
- TP53 NP_000537.3:p.R273S [NCIt concept]
- TP53 NP_000537.3:p.R282G [NCIt concept]
- TP53 NP_000537.3:p.R282W [NCIt concept]
- TP53 NP_000537.3:p.R337H [NCIt concept]
- TP53 NP_000537.3:p.S127Y [NCIt concept]
- TP53 NP_000537.3:p.V272A [NCIt concept]
- TP53 NP_000537.3:p.V272M [NCIt concept]
- TP53 NP_000537.3:p.Y220C [NCIt concept]
- TP53 Protein Variant [NCIt concept]
gene_product_is_element_in_pathway
- ATM Signaling Pathway [NCIt concept]
- Amyotrophic Lateral Sclerosis Pathway [NCIt concept]
- Apoptosis DNA Damage Pathway [NCIt concept]
- BTG Cell Cycle Regulation Pathway [NCIt concept]
- CTCF Pathway [NCIt concept]
- Cancer Susceptibility Pathway [NCIt concept]
- Cell Cycle Progression Pathway [NCIt concept]
- EFP Cell Cycle Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- G2/M Checkpoint Pathway [NCIt concept]
- Huntington's Disease Pathway [NCIt concept]
- Hypoxia Pathway [NCIt concept]
- Interferon Signaling Modulation Pathway [NCIt concept]
- RB Checkpoint Signaling Pathway [NCIt concept]
- Ribosomal Biogenesis Pathway [NCIt concept]
- Telomere Pathway [NCIt concept]
- Tert Regulation Pathway [NCIt concept]
- dsRNA Induction Pathway [NCIt concept]
- p53 Signaling Pathway BioCarta [NCIt concept]
gene_product_malfunction_associated_with_disease
- Adrenal Cortical Carcinoma [NCIt concept]
- Breast Carcinoma [NCIt concept]
- Colorectal Carcinoma [NCIt concept]
- Hepatocellular Carcinoma [NCIt concept]
- Li-Fraumeni Syndrome [NCIt concept]
- Osteosarcoma [NCIt concept]
- Pancreatic Carcinoma [NCIt concept]
- Thyroid Gland Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Aging [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- DNA Repair [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Tumor Suppression [NCIt concept]
is_target
- Adenovirus-p53 Transduced Dendritic Cell Vaccine [NCIt concept]
- Autologous Dendritic Cell-Adenovirus P53 Vaccine [NCIt concept]
- Autologous Dendritic Cells Transduced with Wild-type p53 Adenovirus Vaccine [NCIt concept]
- Azurin:50-77 Cell Penetrating Peptide p28 [NCIt concept]
- Berzofsky Ras/P53 Peptide Vaccine [NCIt concept]
- Cenersen [NCIt concept]
- Contusugene Ladenovec [NCIt concept]
- IL-2 Recombinant Fusion Protein ALT-801 [NCIt concept]
- Modified Vaccinia Virus Ankara Vaccine Expressing p53 [NCIt concept]
- Mutant p53 Activator COTI-2 [NCIt concept]
- Thioureidobutyronitrile [NCIt concept]
- p53 Mutant Reactivator APR-548 [NCIt concept]
- p53 Peptide Vaccine MPS-128 [NCIt concept]

Keyword's position in hierarchy(ies) :

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