Preferred Label : Azurin:50-77 Cell Penetrating Peptide p28;
NCIt synonyms : Azurin:50-77 CPP p28; Azurin-Derived Cell Penetrating Peptide p28;
NCIt related terms : AZURIN-P28;
NCIt definition : A water-soluble, amphipathic, 28 amino acid (amino acids 50-77), 2.9 kD fragment peptide
(p28) derived from the protein azurin with potential antineoplastic and antiangiogenic
activities. Although the mechanism has yet to be fully elucidated, the preferential
cellular uptake of azurin-derived cell-penetrating peptide p28 by tumor cells and
endothelial cells is likely via caveolae-mediated endocytosis; the C-terminal 18 amino
acid residues (50-67) appear to be responsible for this preferential uptake. After
cell entry, the first 12 amino acid residues interact with tumor suppressor p53 and
form a p28:p53 complex, which may result in a reduction of proteasomal degradation
of p53, increased p53 levels, and p53-mediated cell cycle inhibition and apoptosis.
Azurin is a cupredoxin secreted by the bacterium Pseudomonas aeruginosa. Cell penetrating
peptides (CPPs) are cationic and/or amphipathic peptides, typically less than 30 amino
acids in length, that can penetrate cell membranes easily and may transport molecular
cargo.;
UNII : H4QZU9L323;
CAS number : 897026-25-4;
NCI Metathesaurus CUI : CL412365;
Origin ID : C85480;
UMLS CUI : C3252172;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
