Preferred Label : Thioureidobutyronitrile;
NCIt synonyms : Carbamimidothioic Acid, 3-Cyanopropyl Ester;
NCIt related terms : 4-ISOTHIOUREIDOBUTYRONITRILE;
NCIt definition : A water-soluble, small molecule and activator of the tumor suppressor protein p53,
with potential antineoplastic activity. Upon intravenous administration, thioureidobutyronitrile
activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated
modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell
apoptosis. Thioureidobutyronitrile may be effective in drug-resistant cancers with
mutated p53. p53 tumor suppressor, a transcription factor regulating the expression
of many stress response genes and mediating various anti-proliferative processes,
is often mutated in cancer cells.;
UNII : C3059TG1KN;
InChIKey : PRDJGNVQBVXXEO-UHFFFAOYSA-N;
CAS number : 500863-50-3;
Drug name : Kevetrin;
NCI Metathesaurus CUI : CL437184;
Origin ID : C102881;
UMLS CUI : C3640994;
Semantic type(s)
- concept_is_in_subset
- has_target
