Preferred Label : Autologous Dendritic Cells Transduced with Wild-type p53 Adenovirus Vaccine;
NCIt synonyms : Autologous DCs Transduced with Ad.p53 Vaccine; Autologous DCs Transduced with wt p53 Ad Vaccine; Dendritic Cell Based p53 Vaccine; Dendritic Cell-based p53 Vaccine;
NCIt definition : A cancer vaccine consisting of autologous dendritic cells (DCs) transduced with a
recombinant replication-defective adenoviral (Ad) vector encoding the full-length
wild-type (wt) cancer tumor antigen p53 protein (TP53; p53), with potential immunomodulating
activity. Intradermal vaccination with the autologous DCs transduced with wt p53 Ad
vaccine may stimulate the host immune system to mount a cytotoxic T-lymphocyte (CTL)
response against tumor cells overexpressing wt and mutant forms of p53, resulting
in tumor cell lysis. p53, a tumor suppressor gene, is overexpressed and/or mutated
in many tumor cells, resulting in the loss of apoptosis regulation and abnormal cell
proliferation.;
Molecule name : Ad.p53-DC;
NCI Metathesaurus CUI : CL550834;
Origin ID : C148241;
UMLS CUI : C4724926;
Semantic type(s)
- concept_is_in_subset
- has_target
