Hepatocellular Carcinoma

Preferred Label : Hepatocellular Carcinoma;

NCIt synonyms : Primary Carcinoma of the Liver Cells; HCC; Liver Cell Cancer (Hepatocellular Carcinoma); LIHC;

NCIt related terms : Liver cell carcinoma; Hepatoma; Carcinoma of the Liver Cells; CARCINOMA, HEPATOCELLULAR, MALIGNANT; Carcinoma of Liver Cells; Primary Carcinoma of Liver Cells; Hepatocellular Cancer;

NCIt definition : A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation.;

Alternative definition : CDISC: A malignant neoplasm arising from hepatocytes.; NCI-GLOSS: A type of adenocarcinoma and the most common type of liver tumor.;

Neoplastic status : Malignant;

ICD-O code : 8170/3;

Codes from synonyms : 10049010; CDR0000046363; CDR0000046661; C22.0;

Details

Origin ID

C3099;

UMLS CUI

C2239176;

Currated CISMeF NLP mapping
- Carcinoma hepatocellular [MedDRA LLT]
- HEPATIC METASTASES [WHO-ART Included Term]
- Hepatocellular carcinoma [MedDRA Preferred Term]
- Hepatocellular carcinoma [PASCAL descriptor]
- Hepatocellular carcinoma [ACR pathology]
- Hepatocellular carcinoma [HPO term]
- Hepatocellular carcinoma [OMIM Phenotype]
- Hepatocellular carcinoma [ORDO Disease]
- Hepatocellular carcinoma of liver [ICD-11 Sub-sub category]
- Hepatocellular carcinoma, NOS [ICD-11 Extension code]
- Hepatocellular carcinoma, NOS [ICD-O code]
- Hepatoma [MedDRA LLT]
- Liver cell carcinoma [ICD-10 Sub-category]
- Liver cell carcinoma [ICD-10 Sub-category (who)]
- Liver cell carcinoma (disorder) [SNOMED CT concept]
- carcinoma, hepatocellular [MeSH Descriptor]
- carcinoma, hepatocellular [MeSH concept]
- hepatocellular carcinoma [DO Concept]
- hepatocellular carcinoma [Disease (Nov.)]
- hepatocellular carcinoma [Radlex concept]
- hepatocellular carcinoma, nos [SNOMED Notion]
- hepatoma [TUV Concept]
- hepatoma [TUV Term]
DO Cross reference
- hepatocellular carcinoma [DO Concept]
Disease excludes abnormal cell
- Malignant Squamous Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
Disease excludes normal cell origin
- Embryonic Cell [NCIt concept]
Excludes anatomical site(s)
- Extrahepatic Bile Duct [NCIt concept]
- Intrahepatic Bile Duct [NCIt concept]
False automatic mappings
- Hepatocellular carcinoma (morphologic abnormality) [SNOMED CT concept]
HPO term
- Hepatocellular carcinoma [HPO term]
Has associated anatomic sites
- Digestive System [NCIt concept]
- Hepatobiliary System [NCIt concept]
- Liver [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Carcinoma hepatocellular [MedDRA LLT]
- Carcinoma liver [MedDRA LLT]
- Carcinoma of liver [MedDRA LLT]
- HEPATIC METASTASES [WHO-ART Included Term]
- HEPATOMA [WHO-ART Included Term]
- Hepatocellular carcinoma [MedDRA Preferred Term]
- Hepatocellular carcinoma [OMIM Phenotype]
- Hepatocellular carcinoma [HPO term]
- Hepatocellular carcinoma [ORDO Disease]
- Hepatocellular carcinoma [PASCAL descriptor]
- Hepatocellular carcinoma [ACR pathology]
- Hepatocellular carcinoma (morphologic abnormality) [SNOMED CT concept]
- Hepatocellular carcinoma of liver [ICD-11 Sub-sub category]
- Hepatocellular carcinoma, NOS [ICD-O code]
- Hepatoma [MedDRA LLT]
- Liver carcinoma [MedDRA LLT]
- Liver cell carcinoma [ICD-10 Sub-category]
- Liver cell carcinoma [ICD-10 Sub-category (who)]
- Liver cell carcinoma (disorder) [SNOMED CT concept]
- Primary carcinoma of liver (disorder) [SNOMED CT concept]
- Primary liver cell carcinoma (disorder) [SNOMED CT concept]
- carcinoma, hepatocellular [MeSH concept]
- carcinoma, hepatocellular [MeSH Descriptor]
- hepatocellular carcinoma [Radlex concept]
- hepatocellular carcinoma [Disease (Nov.)]
- hepatocellular carcinoma, nos [SNOMED Notion]
- hepatoma [TUV Concept]
- hepatoma [TUV Term]
- liver carcinoma [Disease (Nov.)]
Validated automatic mappings to NTBT
- liver carcinoma [Disease (Nov.)]
associated_with_malfunction_of_gene_product
- ATP-Binding Cassette Sub-Family B Member 6, Mitochondrial [NCIt concept]
- Alpha-Fetoprotein [NCIt concept]
- Cellular Tumor Antigen p53 [NCIt concept]
- Cyclin-A2 [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor 3 [NCIt concept]
- Nucleophosmin [NCIt concept]
- Platelet-Derived Growth Factor Receptor-Like Protein [NCIt concept]
- Rho GTPase-Activating Protein 7 [NCIt concept]
- WAP Four-Disulfide Core Domain Protein 1 [NCIt concept]
concept_is_in_subset
- CDISC SEND Terminology [NCIt concept]
- CDISC SEND Tumor Findings Results Terminology [NCIt concept]
- CPTAC Baseline Medical Forms Terminology [NCIt concept]
- CPTAC Codelists Terminology [NCIt concept]
- CPTAC Liver Hepatocellular Carcinoma Baseline Form [NCIt concept]
- CPTAC Neoplasms Codelist [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- CTS-API Disease Main Type Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
- Clinical Trials Search-Application Programming Interface Disease Category Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NCI CTEP SDC Liver and Hepatobiliary Cancer Sub-Category Terminology [NCIt concept]
- NCI CTEP Simplified Disease Classification Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
- mCode Cancer Disorder Value Set [NCIt concept]
- mCode Elixhauser Malignant Solid Tumors without Metastases Value Set [NCIt concept]
- mCode Primary Cancer Disorder Value Set [NCIt concept]
- mCode Primary Malignant Neoplasm Disorder Value Set [NCIt concept]
- mCode Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Favorable Clinical Outcome [NCIt concept]
- Intermediate Grade Neuroendocrine Lesion [NCIt concept]
- Low Grade Neuroendocrine Lesion [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
- Well Differentiated Neuroendocrine Lesion [NCIt concept]
disease_has_abnormal_cell
- Adenocarcinoma Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
disease_has_associated_gene
- ABCB6 Gene [NCIt concept]
- ABCB6 wt Allele [NCIt concept]
- AFP Gene [NCIt concept]
- AFP wt Allele [NCIt concept]
- AXIN1 Gene [NCIt concept]
- AXIN1 wt Allele [NCIt concept]
- BIN1 Gene [NCIt concept]
- BIN1 wt Allele [NCIt concept]
- CCNA2 Gene [NCIt concept]
- CCNA2 wt Allele [NCIt concept]
- CDKN3 Gene [NCIt concept]
- CDKN3 wt Allele [NCIt concept]
- IGF2R Gene [NCIt concept]
- IGF2R wt Allele [NCIt concept]
- MIR1-1 Gene [NCIt concept]
- MIR1-1 wt Allele [NCIt concept]
- MIR101-1 Gene [NCIt concept]
- MIR101-1 wt Allele [NCIt concept]
- MIR106B Gene [NCIt concept]
- MIR106B wt Allele [NCIt concept]
- MIR122 Gene [NCIt concept]
- MIR122 wt Allele [NCIt concept]
- MIR125B1 Gene [NCIt concept]
- MIR125B1 wt Allele [NCIt concept]
- MIR125B2 Gene [NCIt concept]
- MIR125B2 wt Allele [NCIt concept]
- MIR126 Gene [NCIt concept]
- MIR126 wt Allele [NCIt concept]
- MIR127 Gene [NCIt concept]
- MIR127 wt Allele [NCIt concept]
- MIR130A Gene [NCIt concept]
- MIR130A wt Allele [NCIt concept]
- MIR130B Gene [NCIt concept]
- MIR130B wt Allele [NCIt concept]
- MIR146A Gene [NCIt concept]
- MIR146A wt Allele [NCIt concept]
- MIR16-1 Gene [NCIt concept]
- MIR16-1 wt Allele [NCIt concept]
- MIR16-2 Gene [NCIt concept]
- MIR16-2 wt Allele [NCIt concept]
- MIR17 Gene [NCIt concept]
- MIR17 wt Allele [NCIt concept]
- MIR18A Gene [NCIt concept]
- MIR18A wt Allele [NCIt concept]
- MIR19A Gene [NCIt concept]
- MIR19A wt Allele [NCIt concept]
- MIR19B1 Gene [NCIt concept]
- MIR19B1 wt Allele [NCIt concept]
- MIR19B2 Gene [NCIt concept]
- MIR19B2 wt Allele [NCIt concept]
- MIR200B Gene [NCIt concept]
- MIR200B wt Allele [NCIt concept]
- MIR20A Gene [NCIt concept]
- MIR20A wt Allele [NCIt concept]
- MIR21 Gene [NCIt concept]
- MIR21 wt Allele [NCIt concept]
- MIR221 wt Allele [NCIt concept]
- MIR223 Gene [NCIt concept]
- MIR223 wt Allele [NCIt concept]
- MIR224 Gene [NCIt concept]
- MIR224 wt Allele [NCIt concept]
- MIR24-1 Gene [NCIt concept]
- MIR24-1 wt Allele [NCIt concept]
- MIR24-2 Gene [NCIt concept]
- MIR24-2 wt Allele [NCIt concept]
- MIR25 Gene [NCIt concept]
- MIR25 wt Allele [NCIt concept]
- MIR26A1 Gene [NCIt concept]
- MIR26A1 wt Allele [NCIt concept]
- MIR26A2 Gene [NCIt concept]
- MIR26A2 wt Allele [NCIt concept]
- MIR27A Gene [NCIt concept]
- MIR27A wt Allele [NCIt concept]
- MIR9-1 Gene [NCIt concept]
- MIR9-1 wt Allele [NCIt concept]
- MIR9-2 Gene [NCIt concept]
- MIR9-2 wt Allele [NCIt concept]
- MIR9-3 Gene [NCIt concept]
- MIR9-3 wt Allele [NCIt concept]
- MIR92A1 Gene [NCIt concept]
- MIR92A1 wt Allele [NCIt concept]
- MIR92A2 Gene [NCIt concept]
- MIR92A2 wt Allele [NCIt concept]
- MIRLET7A1 Gene [NCIt concept]
- MIRLET7A1 wt Allele [NCIt concept]
- MIRLET7A3 Gene [NCIt concept]
- MIRLET7A3 wt Allele [NCIt concept]
- PDGFRL Gene [NCIt concept]
- PDGFRL wt Allele [NCIt concept]
- TP53 Gene [NCIt concept]
- TP53 wt Allele [NCIt concept]
- TP53*1 Allele [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
- Hepatocyte [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Hepatic Tissue [NCIt concept]
- Hepatobiliary Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Digestive System [NCIt concept]
- Hepatobiliary System [NCIt concept]
- Liver [NCIt concept]
has_biomarker_gene_product
- Des-Gamma Carboxyprothrombin [NCIt concept]
may_be_associated_disease_of_disease
- BRCA1-Associated Hereditary Breast and Ovarian Cancer Syndrome [NCIt concept]
neoplasm_has_special_category
- Solid Neoplasm [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients