Des-Gamma Carboxyprothrombin

Preferred Label : Des-Gamma Carboxyprothrombin;

NCIt synonyms : PIVKA-II; DCP; Protein Induced by Vitamin K Absence/Antagonist-II; Protein Induced by Vitamin K Absence-II; Protein Induced by Vitamin K Absence or Antagonist II; Des-Gamma-Carboxy Prothrombin;

NCIt definition : Des-gamma carboxyprothrombin (622 aa, 70 kDa) is encoded by the human F2 gene. This protein is involved in blood coagulation. This form of prothrombin is not efficiently converted to the active enzyme thrombin because it lacks gamma-carboxyglutamyl residues. These modified glutamyl residues are absent because of either vitamin K deficiency or inhibition of vitamin K activity that, in turn, inhibits the enzyme that carboxylates these residues, vitamin K-dependent gamma-carboxylase.;

NCIt note : Des-gamma carboxyprothrombin is used in Japan as a biomarker for hepatocellular carcinoma.;

Details

Origin ID

C101804;

UMLS CUI

C3540506;

Automatic exact mappings (from CISMeF team)
- Kartagener syndrome [MeSH Descriptor]
- Paraneoplastic neurologic syndrome [ORDO Disease]
- Primary ciliary dyskinesia [ORDO Disease]
- Protein induced by vitamin K absence or antagonist II [MedDRA Preferred Term]
- dynamic compression plate [Radlex concept]
- dyschondroplasias [MeSH concept]
- obsolete peptidyl-dipeptidase A activity [GO term]
- osteochondrodysplasias [MeSH Descriptor]
- osteochondromatosis syndrome [SNOMED Notion]
- paraneoplastic cerebellar degeneration [MeSH Descriptor]
- paroxysmal pain in patient with cancer pain [Indication]
Currated CISMeF NLP mapping
- Acarboxyprothrombin [LOINC component]
- Des-gamma-carboxy prothrombin (substance) [SNOMED CT concept]
OMIM relation
- Coagulation factor II [OMIM gene]
See also inter- (CISMeF)
- PIVKA II [MedDRA LLT]
- acarboxyprothrombin [MeSH Supplementary Concept]
- acarboxyprothrombin [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Coagulation Factor Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- F2 Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_of
- Hepatocellular Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Coagulation Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Ligand Binding [NCIt concept]
- Proteolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]

Keyword's position in hierarchy(ies) :

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