Cyclin-A2 - CISMeF

Preferred Label : Cyclin-A2;

NCIt synonyms : Cyclin-A; Cyclin A; CCNA2; Cyclin A2;

NCIt definition : Cyclin-A2 (432 aa, 49 kDa) is encoded by the human CCNA2 gene. This protein is involved in the regulation of both the cell cycle and mitosis.;

NCIt note : Cyclin A2 accumulates during G2, is abruptly destroyed at mitosis, controls the cell cycle, and promotes both G1/S and G2/M transitions. Inhibition of cyclin A synthesis or activity inhibits DNA synthesis. Highly conserved cyclins (proliferating cell nuclear antigens) regulate CDK kinases. Cyclin A interacts with CDK2 protein kinase and Ser/Thr kinase p34CDC2 (during G2/M) to form a holoenzyme complex; cyclin imparts substrate specificity to the complex. (LocusLink, Swiss-Prot, OMIM);

Details

Origin ID

C20956;

UMLS CUI

C1608721;

Currated CISMeF NLP mapping
- cyclin A [MeSH concept]
- cyclin A2 [MeSH Descriptor]
- cyclin A2 [MeSH concept]
- cyclin a [MeSH Descriptor]
OMIM relation
- Cyclin a2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CCNA2 protein, human [MeSH Supplementary Concept]
- CCNA2 protein, human [MeSH concept]
- cyclin A2 [MeSH concept]
- cyclin A2 [MeSH Descriptor]
gene_encodes_gene_product
- CCNA2 Gene [NCIt concept]
- Cell Cycle Gene [NCIt concept]
- Cyclin Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Hepatocellular Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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