Hepatocellular carcinoma

Preferred Label : Hepatocellular carcinoma;

CISMeF acronym : HCC; LCC;

Type : Phenotype, molecular basis known;

Alternative titles and symbols : Cancer, hepatocellular; Liver cancer; Liver cell carcinoma; HCC; LCC; HEPATOMA;

Included titles and symbols : Hepatoblastoma; Hepatoblastoma caused by somatic mutation;

Description : Hepatocellular carcinoma is the major histologic type of malignant primary liver neoplasm. It is the fifth most common cancer and the third most common cause of death from cancer worldwide. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. Hepatoblastomas comprise 1-2% of all malignant neoplasms of childhood, most often occurring in children under 3 years of age. Hepatoblastomas are thought to be derived from undifferentiated hepatocytes (Taniguchi et al., 2002).;

Inheritance : Somatic mutation;

Molecular basis : Associated with mutation in the MET protooncogene (MET, 164860.0008); Associated with mutation in the beta-1 catenin gene (CTNNB1, 116806.0013); Associated with mutation in the p53 tumor protein gene (TP53, 191170.0006);

Neoplasia : Primary liver cancer;

Laboratory abnormalities : Often integrated HBV sequences in hepatocellular carcinomas;

Prefixed ID : #114550;

Details

Origin ID

114550;

UMLS CUI

C2239176;

Automatic exact mappings (from CISMeF team)
- Adult Liver Carcinoma [NCIt concept]
- Childhood Hepatocellular Carcinoma [NCIt concept]
- HCCS Gene [NCIt concept]
- HEPATOMA [WHO-ART Included Term]
- Hepatoblastoma [ICD-9 code]
- Hepatoblastoma [ICD-11 Extension code]
- Hepatoblastoma [PASCAL descriptor]
- Hepatoblastoma [ICD-10 Sub-category]
- Hepatoblastoma [ORDO Disease]
- Hepatoblastoma [HPO term]
- Hepatoblastoma [NCIt concept]
- Hepatoblastoma [HRDO Sign]
- Hepatoblastoma [MedDRA Preferred Term]
- Hepatoblastoma [ICD-O code]
- Hepatoblastoma [ICD-11 Sub-sub category]
- Hepatoblastoma (disorder) [SNOMED CT concept]
- Hepatoblastoma (morphologic abnormality) [SNOMED CT concept]
- Hepatoblastomas [MedDRA High Level Term]
- Hollings Cancer Center [NCIt concept]
- Leukoencephalopathy Brain Calcifications and Cysts [MeSH Supplementary Concept]
- Leukoencephalopathy with calcifications and cysts [ORDO Disease]
- Liver Carcinoma [NCIt concept]
- Liver cancer [PASCAL descriptor]
- Liver cancer [HPMULTI term]
- Liver, cancer of [MedDRA LLT]
- Malignant neoplasm of liver [ICD-11 Subcategory]
- Neoplasm of liver (disorder) [SNOMED CT concept]
- Neoplasm of the liver [HPO term]
- cancer of liver [MeSH concept]
- hepatoblastoma [MeSH concept]
- hepatoblastoma [MeSH Descriptor]
- hepatoblastoma [Radlex concept]
- hepatoblastoma [SNOMED Notion]
- hepatoblastoma [DO Concept]
- hepatoblastoma caused by somatic mutation [MeSH concept]
- hepatoblastoma caused by somatic mutation [MeSH Supplementary Concept]
- hyccin PI4KA lipid kinase complex subunit 1 [ORDO Gene]
- liver cancer [DO Concept]
- liver cancer [MedlinePlus Topic]
- liver neoplasms [MeSH Descriptor]
Currated CISMeF NLP mapping
- Carcinoma hepatocellular [MedDRA LLT]
- Hepatocellular Carcinoma [NCIt concept]
- Hepatocellular carcinoma [PASCAL descriptor]
- Hepatocellular carcinoma [HPO term]
- Hepatocellular carcinoma [ORDO Disease]
- Hepatocellular carcinoma [MedDRA Preferred Term]
- Hepatocellular carcinoma [ACR pathology]
- Hepatocellular carcinoma (morphologic abnormality) [SNOMED CT concept]
- Hepatocellular carcinoma of liver [ICD-11 Sub-sub category]
- Hepatocellular carcinoma, NOS [ICD-11 Extension code]
- Hepatocellular carcinoma, NOS [ICD-O code]
- Hepatoma [MedDRA LLT]
- Liver cell carcinoma [ICD-10 Sub-category]
- Liver cell carcinoma [ICD-10 Sub-category (who)]
- Liver cell carcinoma (disorder) [SNOMED CT concept]
- carcinoma, hepatocellular [MeSH Descriptor]
- carcinoma, hepatocellular [MeSH concept]
- hepatocellular carcinoma [DO Concept]
- hepatocellular carcinoma [Disease (Nov.)]
- hepatocellular carcinoma [Radlex concept]
- hepatocellular carcinoma, nos [SNOMED Notion]
DO Cross reference
- hepatocellular carcinoma [DO Concept]
Genes related to phenotype
- Apc regulator of wnt signaling pathway [OMIM gene]
- Axis inhibitor 1 [OMIM gene]
- Caspase 8, apoptosis-related cysteine protease [OMIM gene]
- Catenin, beta-1 [OMIM gene]
- Insulin-like growth factor II receptor [OMIM gene]
- Met protooncogene, receptor tyrosine kinase [OMIM gene]
- Phosphatidylinositol 3-kinase, catalytic, alpha [OMIM gene]
- Platelet-derived growth factor receptor-like [OMIM gene]
- Tumor protein p53 [OMIM gene]
HPO term(s)
- Hepatocellular carcinoma [HPO term]
- Heterogeneous [HPO term]
- Micronodular cirrhosis [HPO term]
- Somatic mutation [HPO term]
- Subacute progressive viral hepatitis [HPO term]
ORDO concept(s)
- Adult hepatocellular carcinoma [ORDO Disease]
- Hepatoblastoma [ORDO Disease]
- Hepatocellular carcinoma [ORDO Disease]
- Pediatric hepatocellular carcinoma [ORDO Disease]
See also inter- (CISMeF)
- hepatoblastoma [Disease (Nov.)]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Carcinoma hepatocellular [MedDRA LLT]
- Carcinoma liver [MedDRA LLT]
- Carcinoma of liver [MedDRA LLT]
- HEPATIC METASTASES [WHO-ART Included Term]
- HEPATOMA [WHO-ART Included Term]
- Hepatocellular Carcinoma [NCIt concept]
- Hepatocellular carcinoma [MedDRA Preferred Term]
- Hepatocellular carcinoma [HPO term]
- Hepatocellular carcinoma [ORDO Disease]
- Hepatocellular carcinoma [ACR pathology]
- Hepatocellular carcinoma [PASCAL descriptor]
- Hepatocellular carcinoma (morphologic abnormality) [SNOMED CT concept]
- Hepatocellular carcinoma of liver [ICD-11 Sub-sub category]
- Hepatocellular carcinoma, NOS [ICD-O code]
- Hepatoma [MedDRA LLT]
- Liver carcinoma [MedDRA LLT]
- Liver cell carcinoma [ICD-10 Sub-category (who)]
- Liver cell carcinoma [ICD-10 Sub-category]
- Liver cell carcinoma (disorder) [SNOMED CT concept]
- Primary carcinoma of liver (disorder) [SNOMED CT concept]
- Primary liver cell carcinoma (disorder) [SNOMED CT concept]
- carcinoma, hepatocellular [MeSH Descriptor]
- carcinoma, hepatocellular [MeSH concept]
- hepatocellular carcinoma [Radlex concept]
- hepatocellular carcinoma [Disease (Nov.)]
- hepatocellular carcinoma, nos [SNOMED Notion]
- hepatoma [TUV Concept]
- hepatoma [TUV Term]
- liver carcinoma [Disease (Nov.)]
Validated automatic mappings to BTNT
- Adult Hepatocellular Carcinoma [NCIt concept]
Validated automatic mappings to NTBT
- Malignant neoplasm of liver (disorder) [SNOMED CT concept]
- liver cancer [Disease (Nov.)]
- liver carcinoma [Disease (Nov.)]

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