Preferred Label : Hepatocellular carcinoma;
CISMeF acronym : HCC; LCC;
Type : Phenotype, molecular basis known;
Alternative titles and symbols : Cancer, hepatocellular; Liver cancer; Liver cell carcinoma; HCC; LCC; HEPATOMA;
Included titles and symbols : Hepatoblastoma; Hepatoblastoma caused by somatic mutation;
Description : Hepatocellular carcinoma is the major histologic type of malignant primary liver neoplasm.
It is the fifth most common cancer and the third most common cause of death from cancer
worldwide. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection,
chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic
cirrhosis, and cirrhosis due to other causes. Hepatoblastomas comprise 1-2% of all
malignant neoplasms of childhood, most often occurring in children under 3 years of
age. Hepatoblastomas are thought to be derived from undifferentiated hepatocytes (Taniguchi
et al., 2002).;
Inheritance : Somatic mutation;
Molecular basis : Associated with mutation in the MET protooncogene (MET, 164860.0008); Associated with mutation in the beta-1 catenin gene (CTNNB1, 116806.0013); Associated with mutation in the p53 tumor protein gene (TP53, 191170.0006);
Neoplasia : Primary liver cancer;
Laboratory abnormalities : Often integrated HBV sequences in hepatocellular carcinomas;
Prefixed ID : #114550;
Origin ID : 114550;
UMLS CUI : C2239176;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- DO Cross reference
- Genes related to phenotype
- HPO term(s)
- ORDO concept(s)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- Validated automatic mappings to NTBT
