Preferred Label : MIR221 wt Allele;
NCIt synonyms : MIRN221; MicroRNA 221 wt Allele; hsa-mir-221; Micro RNA 221 Gene; mir-221; miRNA221;
NCIt definition : Human MIR221 wild-type allele is located in the vicinity of Xp11.3 and is 109 bases
in length. This allele, which encodes the MIR221 pre-miRNA, plays a role in the regulation
of gene expression. Alteration in the expression of this gene is associated with the
development of cancers of the liver, ovary, breast, lung, thyroid and prostate, as
well as melanoma and glioblastoma multiforme.;
NCIt note : MIR221 is overexpressed in thyroid cancer, glioblastoma, pancreatic cancer, and prostate
cancer. Galardi suggested that MIR221 targets p27.;
GenBank Accession Number : NT_079573;
miRBase ID : MI0000298;
Origin ID : C82171;
UMLS CUI : C2826019;
Automatic exact mappings (from CISMeF team)
- OMIM relation
- Semantic type(s)
- concept_is_in_subset
- gene_associated_with_disease
- gene_found_in_organism
- gene_in_chromosomal_location
- gene_plays_role_in_process
