Glioblastoma - CISMeF

Preferred Label : Glioblastoma;

NCIt synonyms : GBM (Glioblastoma); Spongioblastoma Multiforme;

NCIt related terms : GBM; Glioblastoma multiforme; CNS, glioblastoma (GBM);

NCIt definition : The most malignant astrocytic tumor (WHO grade 4). It is composed of poorly differentiated neoplastic astrocytes and is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation, and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. (Adapted from WHO);

Alternative definition : NCI-GLOSS: A fast-growing type of central nervous system tumor that forms from glial (supportive) tissue of the brain and spinal cord and has cells that look very different from normal cells. GBM usually occurs in adults and affects the brain more often than the spinal cord.;

NCIt note : Glioblastoma is not an astrocytoma. It is an astrocytic tumor. The latter includes astrocytomas and glioblastomas. However, when an anaplastic astrocytoma progresses to grade IV tumor, it is called a glioblastoma.;

Neoplastic status : Malignant;

ICD-O code : 9440/3;

Codes from synonyms : 10018337; CDR0000539131; CDR0000045698; CDR0000045699;

Details

Origin ID

C3058;

UMLS CUI

C1621958;

Automatic exact mappings (from CISMeF team)
- Glioblastoma, primary, NOS [ICD-11 Extension code]
- Glioma susceptibility 1 [OMIM Phenotype]
- glomerular basement membrane [UBERON concept]
Currated CISMeF NLP mapping
- Glioblastoma [PASCAL descriptor]
- Glioblastoma [MedDRA Preferred Term]
- Glioblastoma [ORDO Disease]
- Glioblastoma (morphologic abnormality) [SNOMED CT concept]
- Glioblastoma multiforme [HPO term]
- Glioblastoma multiforme [PASCAL descriptor]
- Glioblastoma multiforme [MedDRA Preferred Term]
- Glioblastoma multiforme (disorder) [SNOMED CT concept]
- Glioblastoma, NOS [ICD-O code]
- astrocytoma WHO grade IV [Radlex concept]
- glioblastoma [DO Concept]
- glioblastoma [MeSH Descriptor]
- glioblastoma [MeSH concept]
- glioblastoma multiforme [MeSH concept]
- glioblastoma, nos [SNOMED Notion]
- obsolete Glioblastoma [HPO term]
Disease may have findings
- Headache [NCIt concept]
- Seizure [NCIt concept]
- Unfavorable Clinical Outcome [NCIt concept]
Has associated anatomic sites
- Central Nervous System [NCIt concept]
- Nervous System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Glioblastoma [ORDO Disease]
- Glioblastoma [PASCAL descriptor]
- Glioblastoma [MedDRA Preferred Term]
- Glioblastoma (morphologic abnormality) [SNOMED CT concept]
- Glioblastoma multiforme [MedDRA Preferred Term]
- Glioblastoma multiforme [HPO term]
- Glioblastoma multiforme (disorder) [SNOMED CT concept]
- Glioblastoma, NOS [ICD-O code]
- Glioblastoma, no International Classification of Diseases for Oncology subtype (morphologic abnormality) [SNOMED CT concept]
- astrocytoma WHO grade IV [Radlex concept]
- glioblastoma [MeSH concept]
- glioblastoma [MeSH Descriptor]
- glioblastoma multiforme [MeSH concept]
- glioblastoma multiforme [Disease (Nov.)]
- glioblastoma, nos [SNOMED Notion]
- obsolete Glioblastoma [HPO term]
Validated automatic mappings to BTNT
- Glioblastoma, no International Classification of Diseases for Oncology subtype (morphologic abnormality) [SNOMED CT concept]
- glioblastoma multiforme [Disease (Nov.)]
associated_with_malfunction_of_gene_product
- Isocitrate Dehydrogenase [NADP] Cytoplasmic [NCIt concept]
- YEATS Domain-Containing Protein 4 [NCIt concept]
- Zinc Finger Protein GLI1 [NCIt concept]
concept_is_in_subset
- CPTAC Baseline Medical Forms Terminology [NCIt concept]
- CPTAC Codelists Terminology [NCIt concept]
- CPTAC Follow-Up Forms Terminology [NCIt concept]
- CPTAC Glioblastoma Multiforme Baseline Form [NCIt concept]
- CPTAC Glioblastoma Multiforme Follow-Up Form [NCIt concept]
- CPTAC Neoplasms Codelist [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTS-API Disease Main Type Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Clinical Trials Search-Application Programming Interface Disease Category Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NCI CTEP SDC Astrocytoma, High Grade Sub-Category Terminology [NCIt concept]
- NCI CTEP Simplified Disease Classification Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Indolent Clinical Course [NCIt concept]
- Precise Histogenesis Unknown [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Neoplastic Astrocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Glial Cell [NCIt concept]
- Neoplastic Neuroepithelial Cell [NCIt concept]
- Neoplastic Neuroepithelial Cell and Neoplastic Perineural Cell [NCIt concept]
- Poorly Differentiated Neoplastic Astrocyte [NCIt concept]
disease_has_associated_disease
- Turcot Syndrome Type 1 [NCIt concept]
disease_has_associated_gene
- ERBB2 Gene [NCIt concept]
- ERBB2 wt Allele [NCIt concept]
- IDH1 wt Allele [NCIt concept]
- MIR124-1 Gene [NCIt concept]
- MIR124-1 wt Allele [NCIt concept]
- MIR137 Gene [NCIt concept]
- MIR137 wt Allele [NCIt concept]
- MIR21 Gene [NCIt concept]
- MIR21 wt Allele [NCIt concept]
- MIR221 Gene [NCIt concept]
- MIR221 wt Allele [NCIt concept]
- MIR222 Gene [NCIt concept]
- MIR222 wt Allele [NCIt concept]
- MIR451A Gene [NCIt concept]
- MIR451A wt Allele [NCIt concept]
- MIRLET7A1 Gene [NCIt concept]
- MIRLET7A1 wt Allele [NCIt concept]
- MIRLET7A3 Gene [NCIt concept]
- MIRLET7A3 wt Allele [NCIt concept]
- YEATS4 Gene [NCIt concept]
- YEATS4 wt Allele [NCIt concept]
disease_has_finding
- Anaplastic Lesion [NCIt concept]
- Diffuse Pattern [NCIt concept]
- High Grade Lesion [NCIt concept]
- Infiltrative Growth Pattern [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Microvascular Proliferation [NCIt concept]
- Mitotic Activity [NCIt concept]
- Necrotic Change [NCIt concept]
- Nuclear Atypia [NCIt concept]
disease_has_grade
- Grade 4 [NCIt concept]
- High Grade [NCIt concept]
disease_has_normal_cell_origin
- Astrocyte [NCIt concept]
- Glial Cell [NCIt concept]
- Neuroepithelial Cell [NCIt concept]
- Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System [NCIt concept]
disease_has_normal_tissue_origin
- Nerve Tissue, Neuroepithelial Tissue, and Nerve Sheaths [NCIt concept]
- Neuroepithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Central Nervous System [NCIt concept]
disease_may_have_molecular_abnormality
- PTEN Gene Inactivation [NCIt concept]
human_disease_maps_to_eo_disease
- Mouse Giant Cell Glioblastoma [NCIt concept]
- Mouse Glioblastoma [NCIt concept]
- Mouse Gliosarcoma [NCIt concept]
neoplasm_has_special_category
- Solid Neoplasm [NCIt concept]

Keyword's position in hierarchy(ies) :

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