Zinc Finger Protein GLI1

Preferred Label : Zinc Finger Protein GLI1;

NCIt synonyms : GLI1; GLI1 Protein; GLI; Oncogene GLI; Glioma-Associated Oncogene; Glioma Associated Oncogene Homolog 1 Protein; GLI Protein; Glioma-Associated Oncogene Family Zinc Finger 1; GLI-Kruppel Family Member GLI1;

NCIt definition : Zinc finger protein GLI1 (1106 aa, 118 kDa) is encoded by the human GLI1 gene. This protein is involved in transcriptional regulation, cell differentiation and signaling pathway modulation.;

NCIt note : The GLI1 Protein, a Kruppel family protein, is homologous to Drosophila Cubitus interruptus and contains five DNA-binding zinc finger repeats, implicated in transduction of the SHH signal; an endodermal signal that controls hindgut patterning and lung growth. The GLI1 gene is found amplified in a malignant glioma. (from OMIM);

Details

Origin ID

C18171;

UMLS CUI

C1449308;

OMIM relation
- Gli family zinc finger 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GLI1 protein, human [MeSH concept]
- GLI1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- GLI1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_expressed_in_tissue
- Fallopian Tube [NCIt concept]
- Myometrium [NCIt concept]
- Testis [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- GLI Family Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- C2H2 Zinc Finger [NCIt concept]
gene_product_is_element_in_pathway
- Basal Cell Carcinoma Pathway [NCIt concept]
- Hedgehog Signaling Events Mediated by Gli Family Proteins [NCIt concept]
- Hedgehog Signaling Pathway [NCIt concept]
- Sonic Hedgehog Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Glioblastoma [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Pattern Formation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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