Isocitrate Dehydrogenase [NADP] Cytoplasmic

Preferred Label : Isocitrate Dehydrogenase [NADP] Cytoplasmic;

NCIt synonyms : IDH; Cytosolic NADP-Isocitrate Dehydrogenase; NADP ( )-specific ICDH; EC 1.1.1.42; IDP; Oxalosuccinate Decarboxylase; IDH1; Isocitrate Dehydrogenase NADP Cytoplasmic;

NCIt definition : Isocitrate dehydrogenase [NADP] cytoplasmic (414 aa, 47 kDa) is encoded by the human IDH1 gene. This protein plays a role the oxidation of isocitrate and oxalosuccinate.;

Détails

Origin ID

C77217;

UMLS CUI

C2697821;

OMIM relation
- Isocitrate dehydrogenase, nadp(+), 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Pediatric Oncology Target Genes/Proteins Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- IDH1 Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_gene_product_variant
- IDH1 NP_005887.2:p.R119Q [NCIt concept]
- IDH1 NP_005887.2:p.R132C [NCIt concept]
- IDH1 NP_005887.2:p.R132G [NCIt concept]
- IDH1 NP_005887.2:p.R132H [NCIt concept]
- IDH1 NP_005887.2:p.R132L [NCIt concept]
- IDH1 NP_005887.2:p.R132S [NCIt concept]
- IDH1 NP_005887.2:p.R132V [NCIt concept]
- IDH1 NP_005887.2:p.R132X [NCIt concept]
- IDH1 Protein Variant [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Citrate Cycle (TCA Cycle) Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Glioblastoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Carbohydrate Metabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
is_target
- Hyperpolarized Carbon 13 Alpha-ketoglutarate [NCIt concept]
- IDH1 Inhibitor KY100001 [NCIt concept]
- IDH1 Inhibitor TQB3454 [NCIt concept]
- Ivosidenib [NCIt concept]
- Olutasidenib [NCIt concept]
- Ranosidenib [NCIt concept]
- Safusidenib [NCIt concept]
- Vorasidenib [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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