Preferred Label : Hyperpolarized Carbon 13 Alpha-ketoglutarate;
NCIt synonyms : Hyperpolarized 13C-aKG; HP 13C-aKG; Hyperpolarized Carbon-13 Alpha-ketoglutarate; HP C13-aKG; HP Carbon-13 aKG;
NCIt definition : A radioconjugate and dynamic nuclear polarization (DNP) metabolic imaging probe composed
of hyperpolarized alpha-ketoglutarate (aKG) labeled with carbon C 13, with potential
usage in the diagnostic imaging of isocitrate dehydrogenase 1 (IDH1) mutant-expressing
cancer cells upon magnetic resonance imaging (MRI). Upon administration, hyperpolarized
carbon C 13 aKG (HP 13C-aKG) is taken up by IDH1-expressing cancer cells. In tumors
that express wild-type IDH1, only HP 13C-aKG can be detected. In cells that express
mutant IDH1, HP 13C-aKG is further metabolized to HP 13C-2-hydroxyglutarate (HP 13C-2-HG)
while not in tumor cells expressing wild-type IDH1 or in normal, healthy brain tissue.
Upon nuclear magnetic resonance (NMR)-based imaging, HP 13C-aKG is detected in wild-type
IDH1-expressing cancer cells, and both HP 13C-aKG and HP 13C-2-HG can be detected
in IDH1 mutant-expressing cancer cells though HP 13C-aKG detection decreases in IDH1-mutant-expressing
cancer cells over time due to conversion to HP 13C-2-HG. This may aid in the diagnosis
of cancers expressing IDH1 and provides mutant IDH1 status of tumor cells.;
NCI Metathesaurus CUI : CL1906748;
Origin ID : C199371;
UMLS CUI : C5855549;
Semantic type(s)
- concept_is_in_subset
- has_target
