Preferred Label : Citrate Cycle (TCA Cycle) Pathway;
NCIt synonyms : Citrate Cycle TCA Cycle Pathway;
NCIt related terms : Citrate Cycle (TCA cycle);
Alternative definition : KEGG: The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for
the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts
with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate
oxidation of carbohydrates and from beta oxidation of fatty acids. The two-carbon
acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate
to form the six-carbon compound of citrate. In a series of reactions two carbons in
citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the
oxidative phosphorylation and other metabolic processes. The pathway also supplies
important precursor metabolites including 2-oxoglutarate. At the end of the cycle
the remaining four-carbon part is transformed back to oxaloacetate. According to the
genome sequence data, many organisms seem to lack genes for the full cycle, but contain
genes for specific segments.;
KEGG ID : hsa00020;
Origin ID : C38797;
UMLS CUI : C1516586;
Semantic type(s)
has_gene_product_element
pathway_has_gene_element