Citrate Cycle (TCA Cycle) Pathway

Preferred Label : Citrate Cycle (TCA Cycle) Pathway;

NCIt synonyms : Citrate Cycle TCA Cycle Pathway;

NCIt related terms : Citrate Cycle (TCA cycle);

Alternative definition : KEGG: The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation of carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle, but contain genes for specific segments.;

KEGG ID : hsa00020;

Details

Origin ID

C38797;

UMLS CUI

C1516586;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Dihydrolipoyllysine-Residue Succinyltransferase Component of 2-Oxoglutarate Dehydrogenase Complex, Mitochondrial [NCIt concept]
- Fumarate Hydratase, Mitochondrial [NCIt concept]
- Isocitrate Dehydrogenase [NADP] Cytoplasmic [NCIt concept]
- Malate Dehydrogenase, Mitochondrial [NCIt concept]
- Pyruvate Carboxylase, Mitochondrial [NCIt concept]
- Succinate Dehydrogenase Cytochrome b560 Subunit, Mitochondrial [NCIt concept]
- Succinate Dehydrogenase [Ubiquinone] Cytochrome B Small Subunit, Mitochondrial [NCIt concept]
- Succinate Dehydrogenase [Ubiquinone] Flavoprotein Subunit, Mitochondrial [NCIt concept]
- Succinate Dehydrogenase [Ubiquinone] Iron-Sulfur Subunit, Mitochondrial [NCIt concept]
pathway_has_gene_element
- DLST wt Allele [NCIt concept]
- FH wt Allele [NCIt concept]
- IDH1 wt Allele [NCIt concept]
- MDH2 wt Allele [NCIt concept]
- PC wt Allele [NCIt concept]
- SDHA wt Allele [NCIt concept]
- SDHB wt Allele [NCIt concept]
- SDHC wt Allele [NCIt concept]
- SDHD wt Allele [NCIt concept]

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