Malate Dehydrogenase, Mitochondrial

Preferred Label : Malate Dehydrogenase, Mitochondrial;

NCIt synonyms : EC 1.1.1.37; MDH2;

NCIt definition : Malate dehydrogenase, mitochondrial (338 aa, 36 kDa) is encoded by the human MDH2 gene. This protein plays a role in the conversion of malate to oxaloacetate.;

NCIt note : Malate dehydrogenase, mitochondrial catalyzes the reversible oxidation of malate to oxaloacetate, while utilizing the NAD/NADH cofactor system in the citric acid cycle. (EntrezGene and UniProt);

Details

Origin ID

C124985;

UMLS CUI

C4083833;

Automatic exact mappings (from CISMeF team)
- Malate dehydrogenase, mitochondrial [OMIM gene]
- malate dehydrogenase 2 [ORDO Gene]
OMIM relation
- Malate dehydrogenase, mitochondrial [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MDH2 Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Mitochondrial Matrix [NCIt concept]
gene_product_has_biochemical_function
- Malate Dehydrogenase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Citrate Cycle (TCA Cycle) Pathway [NCIt concept]
- Cysteine and Methionine Metabolism Pathway [NCIt concept]
- Glyoxylate and Dicarboxylate Metabolism Pathway [NCIt concept]
- Pyruvate Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Respiration [NCIt concept]
- Gluconeogenic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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