NCIt definition : The biosynthesis of new glucose as opposed to that generated by the metabolism of
glycogen. Gluconeogenesis occurs mainly in the liver or kidneys, and involves the
biosynthesis of glucose from 3-carbon or 4-carbon non-carbohydrate precursors such
as amino acids or fats.;
Alternative definition : NCI-GLOSS: The process of making glucose (sugar) from its own breakdown products or
from the breakdown products of lipids (fats) or proteins. Gluconeogenesis occurs mainly
in cells of the liver or kidney.;