Alanine Aminotransferase

Preferred Label : Alanine Aminotransferase;

NCIt synonyms : ALT; SGPT-ALT Protein; Serum Glutamate-Pyruvate Transaminase; EC 2.6.1.2; ALAT; SGPT (ALT); Alanine Transaminase; Serum Glutamic-Pyruvic Transaminase;

NCIt related terms : SGPT; serum glutamate pyruvate transaminase; alanine transferase;

NCIt definition : A family of pyridoxal phosphate-dependent enzymes involved in cellular nitrogen metabolism, amino acid metabolism, and liver gluconeogenesis. Alanine aminotransferase specifically and reversibly catalyzes the transfer of an amino group from L-alanine to alpha-ketoglutarate forming pyruvate and L-glutamate.;

Alternative definition : NCI-GLOSS: An enzyme found in the liver and other tissues. A high level of serum glutamate pyruvate transaminase released into the blood may be a sign of liver damage, cancer, or other diseases.;

Codes from synonyms : CDR0000372947; CDR0000372944; CDR0000372943;

Détails

Origin ID

C25293;

UMLS CUI

C0001899;

Automatic exact mappings (from CISMeF team)
- ALT high [MedDRA LLT]
- L-alanine:2-oxoglutarate aminotransferase activity [GO term]
- N-acetyllysyl-arginyl-tyrosyl-asparaginyl-leucinamide [MeSH Supplementary Concept]
- SGPT [MedDRA LLT]
- SGPT [MeSH concept]
- Well-differentiated liposarcoma [ORDO Disease]
- alanine aminotransferase [Artificial nutrition thesaurus concept]
- glutamic--pyruvic transaminase [HGNC gene]
Currated CISMeF NLP mapping
- Alanine amino-transferase [ICHI extension code]
- Alanine aminotransferase [LOINC component]
- Alanine aminotransferase [MedDRA Preferred Term]
- Alanine aminotransferase [LOINC part]
- Alanine aminotransferase (substance) [SNOMED CT concept]
- alanine amino-transferase [EMDN type]
- alanine aminotransferase [medical devices type]
- alanine aminotransferase [SNOMED Notion]
- alanine transaminase [MeSH Descriptor]
- alanine transaminase [MeSH concept]
False automatic mappings
- HIV Non-Progressors [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Alanine aminotransferase [LOINC part]
- Alanine aminotransferase [LOINC component]
- Alanine aminotransferase (substance) [SNOMED CT concept]
- SGPT [MeSH concept]
- alanine aminotransferase [SNOMED Notion]
- alanine transaminase [MeSH Descriptor]
- alanine transaminase [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Gluconeogenic Process [NCIt concept]
- Protein Metabolism Process [NCIt concept]

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