Glucose-6-Phosphate Isomerase

Preferred Label : Glucose-6-Phosphate Isomerase;

NCIt synonyms : Hexosephosphate Isomerase; Hexose Monophosphate Isomerase; Phosphosaccharomutase; Sperm Antigen-36; Phosphohexose Isomerase; SA-36; Glucosephosphate Isomerase; Phosphohexomutase; Phosphoglucose Isomerase; AMF; GPI; Autocrine Motility Factor; D-Glucose-6-Phosphate Ketol-Isomerase; Oxoisomerase; EC 5.3.1.9; Neuroleukin; PHI; Glucose Phosphate Isomerase; PGI; NLK; Sperm Antigen 36;

NCIt definition : Glucose-6-phosphate isomerase (558 aa, 63 kDa) is encoded by the human GPI gene. This protein is involved in glycolysis in as a cytoplasmic homodimer and has a secreted monomeric form that either exhibits cytokine activity or can function as a neurotrophic factor.;

NCIt note : The enzymatically active form of glucose-6-phosphate isomerase (GPI) is a cytosolic homodimer. GPI expresses cytokine activity when secreted as a monomer. (UniProt);

Details

Origin ID

C17428;

UMLS CUI

C2975867;

OMIM relation
- Glucose-6-phosphate isomerase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- GPI protein, human [MeSH concept]
- GPI protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- GPI Gene [NCIt concept]
- Isomerase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Lymphokine [NCIt concept]
- Neurotrophic Factor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Amino and Nucleotide Sugars Metabolism Pathway [NCIt concept]
- Glycolysis Pathway [NCIt concept]
- Glycolysis/Gluconeogenesis Pathway [NCIt concept]
- Pentose Phosphate Cycle Pathway [NCIt concept]
- Starch and Sucrose Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- B-Cell Activation [NCIt concept]
- Cell Motility [NCIt concept]
- Gluconeogenic Process [NCIt concept]
- Glycolysis [NCIt concept]
- Intercellular Communication Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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