Glycolysis/Gluconeogenesis Pathway

Preferred Label : Glycolysis/Gluconeogenesis Pathway;

NCIt synonyms : Glycolysis Gluconeogenesis Pathway;

NCIt related terms : Glycolysis / Gluconeogenesis;

Alternative definition : KEGG: Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module, which is found in almost all organisms and which often corresponds to operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from non-carbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths.;

KEGG ID : hsa00010;

Details

Origin ID

C38818;

UMLS CUI

C1512230;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- 6-Phosphofructokinase, Muscle Type [NCIt concept]
- Acetyl-Coenzyme A Synthetase, Cytoplasmic [NCIt concept]
- Alcohol Dehydrogenase 1C [NCIt concept]
- Alcohol Dehydrogenase 4 [NCIt concept]
- Aldehyde Dehydrogenase X, Mitochondrial [NCIt concept]
- Aldehyde Dehydrogenase, Mitochondrial [NCIt concept]
- Bisphosphoglycerate Mutase [NCIt concept]
- Fructose-1,6-Bisphosphatase 1 [NCIt concept]
- Galactose Mutarotase [NCIt concept]
- Gamma-Enolase [NCIt concept]
- Glucose-6-Phosphatase 3 [NCIt concept]
- Glucose-6-Phosphate Isomerase [NCIt concept]
- Hexokinase-1 [NCIt concept]
- Hexokinase-2 [NCIt concept]
- Hexokinase-4 [NCIt concept]
- L-Lactate Dehydrogenase A Chain [NCIt concept]
- L-Lactate Dehydrogenase B Chain [NCIt concept]
- Phosphoglycerate Kinase 1 [NCIt concept]
- Phosphoglycerate Mutase 1 [NCIt concept]
- Pyruvate Kinase PKLR [NCIt concept]
- Pyruvate Kinase PKLR Isoform L-Type [NCIt concept]
- Pyruvate Kinase PKM [NCIt concept]
- Triosephosphate Isomerase [NCIt concept]
pathway_has_gene_element
- ADH1C wt Allele [NCIt concept]
- ADH4 wt Allele [NCIt concept]
- ALDH1B1 wt Allele [NCIt concept]
- ALDH2 wt Allele [NCIt concept]
- BPGM wt Allele [NCIt concept]
- ENO2 wt Allele [NCIt concept]
- FBP1 wt Allele [NCIt concept]
- G6PC3 wt Allele [NCIt concept]
- GALM wt Allele [NCIt concept]
- GCK wt Allele [NCIt concept]
- GPI wt Allele [NCIt concept]
- HK1 wt Allele [NCIt concept]
- HK2 wt Allele [NCIt concept]
- LDHA wt Allele [NCIt concept]
- LDHB wt Allele [NCIt concept]
- PFKM wt Allele [NCIt concept]
- PGAM1 wt Allele [NCIt concept]
- PGK1 wt Allele [NCIt concept]
- PKLR wt Allele [NCIt concept]
- PKM wt Allele [NCIt concept]
- TPI1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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