PKM wt Allele - CISMeF

Preferred Label : PKM wt Allele;

NCIt synonyms : PK3; PK2; TCB; THBP1; MGC3932; Pyruvate Kinase, Muscle wt Allele; OIP3; CTHBP; Thyroid Hormone-Binding Protein, Cytosolic Gene; PKM2; PK, Muscle Type Gene; HEL-S-30; PKM2 wt Allele;

NCIt definition : Human PKM wild-type allele is located in the vicinity of 15q23 and is approximately 33 kb in length. This allele, which encodes pyruvate kinase PKM protein, plays a role in the progression of glycolysis. Aberrant expression of the M2 isoform of the gene may be involved in the regulation of cancer cell growth and proliferation.;

GenBank Accession Number : M23725;

Details

Origin ID

C74442;

UMLS CUI

C2698696;

OMIM relation
- Pyruvate kinase, muscle [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 15q23 [NCIt concept]
gene_is_element_in_pathway
- Glycolysis/Gluconeogenesis Pathway [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- Purine Metabolism Pathway [NCIt concept]
- Pyruvate Metabolism Pathway [NCIt concept]
- Type II Diabetes Mellitus Pathway [NCIt concept]
gene_plays_role_in_process
- Glycolysis [NCIt concept]
- Phosphorylation Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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